Evidence map›Paper›PMID 37345187›Full record

ArticleCancers2023

Transfer-Learning Deep Radiomics and Hand-Crafted Radiomics for Classifying Lymph Nodes from Contrast-Enhanced Computed Tomography in Lung Cancer.

Fabian Christopher Laqua, Piotr Woznicki, Thorsten A Bley, Mirjam Schöneck, Miriam Rinneburger, Mathilda Weisthoff, Matthias Schmidt, Thorsten Persigehl, Andra-Iza Iuga, Bettina Baeßler

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Fabian Christopher LaquaDepartment of Diagnostic and Interventional Radiology, University Hospital Würzburg, University of Würzburg, 97080 Würzburg, Germany.ORCID 0000-0002-3761-0350
Piotr WoznickiDepartment of Diagnostic and Interventional Radiology, University Hospital Würzburg, University of Würzburg, 97080 Würzburg, Germany.
Thorsten A BleyDepartment of Diagnostic and Interventional Radiology, University Hospital Würzburg, University of Würzburg, 97080 Würzburg, Germany.
Mirjam SchöneckInstitute of Diagnostic and Interventional Radiology, Medical Faculty and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
Miriam RinneburgerInstitute of Diagnostic and Interventional Radiology, Medical Faculty and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
Mathilda WeisthoffInstitute of Diagnostic and Interventional Radiology, Medical Faculty and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.ORCID 0000-0001-6536-3898
Matthias SchmidtDepartment of Nuclear Medicine, Medical Faculty and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
Thorsten PersigehlInstitute of Diagnostic and Interventional Radiology, Medical Faculty and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
Andra-Iza IugaInstitute of Diagnostic and Interventional Radiology, Medical Faculty and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.ORCID 0000-0002-3694-0235
Bettina BaeßlerDepartment of Diagnostic and Interventional Radiology, University Hospital Würzburg, University of Würzburg, 97080 Würzburg, Germany.
University of Cologne · DEUniversity of Würzburg · DE

Funding

Deutsche Forschungsgemeinschaft 428219815/ SPP 2177
6 · The paper itself

Abstract

objectivesPositron emission tomography (PET) is currently considered the non-invasive reference standard for lymph node (N-)staging in lung cancer. However, not all patients can undergo this diagnostic procedure due to high costs, limited availability, and additional radiation exposure. The purpose of this study was to predict the PET result from traditional contrast-enhanced computed tomography (CT) and to test different feature extraction strategies.

methodsIn this study, 100 lung cancer patients underwent a contrast-enhanced

resultsIn total, 2734 lymph nodes [555 (20.3%) PET-positive] from 100 patients [49% female; mean age 65, SD: 14] with lung cancer (60% adenocarcinoma, 21% plate epithelial carcinoma, 8% small-cell lung cancer) were included in this study. The area under the receiver operating characteristic curve (AUC) ranged from 0.79 to 0.87, and the scaled Brier score (SBS) ranged from 16 to 36%. The random forest model (iii) yielded the best results [AUC 0.871 (0.865-0.878), SBS 35.8 (34.2-37.2)] and had significantly higher model performance than both approaches alone (AUC:

conclusionBoth traditional radiomics features and transfer-learning deep radiomics features provide relevant and complementary information for non-invasive N-staging in lung cancer.

Indexed as

carcinomacomputational neural networkscomputed tomographylymphatic metastasisnon-small-cell lungsmall-cell lung

Identifiers

PMID37345187
PMCPMC10216416
OpenAlexW4377290647

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.