Evidence map›Paper›PMID 37345175›Full record

ArticleCancers2023

Clinical Outcomes of Patients with Metastatic Breast Cancer Treated with Hypo-Fractionated Liver Radiotherapy.

Melinda Mushonga, Joelle Helou, Jessica Weiss, Laura A Dawson, Rebecca K S Wong, Ali Hosni, John Kim, James Brierley, C Anne Koch, Khalid Alrabiah and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 76% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Melinda MushongaRadiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada.ORCID 0000-0002-3983-4892
Joelle HelouRadiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada.
Jessica WeissDepartment of Biostatistics, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.
Laura A DawsonRadiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada.
Rebecca K S WongRadiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada.
Ali HosniRadiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada.
John KimRadiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada.
James BrierleyRadiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada.
C Anne KochRadiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada.
Khalid AlrabiahRadiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada.
Patricia LindsayRadiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada.
Teo StanescuRadiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada.
Aisling BarryRadiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada.ORCID 0000-0003-2734-7090
University of Toronto · CAUniversity Health Network · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo retrospectively review the clinical outcomes of patients with metastatic breast cancer (MBCa) following liver directed ablative intent radiotherapy (RT).

methodsDemographics, disease and treatment characteristics of patients with MBCa who received liver metastasis (LM) directed ablative RT between 2004-2020 were analysed. The primary outcome was local control (LC), secondary outcomes included overall survival (OS) and progression-free survival (PFS) analyzed by univariate (UVA) and multi-variable analysis (MVA).

resultsThirty MBCa patients with 50 LM treated with 5-10 fraction RT were identified. Median follow-up was 14.6 (range 0.9-156.2) months. Class of metastatic disease was described as induced (12 patients, 40%), repeat (15 patients, 50%) and de novo (three patients, 10%). Median size of treated LM was 3.1 cm (range 1-8.8 cm) and median biologically effective dose delivered was 122 (Q1-Q3; 98-174) Gy

conclusionsHypo-fractionated ablative liver RT in patients with MBCa provides safe, tolerable treatment with excellent LC.

Indexed as

ablative radiotherapybreast cancerliver metastasismetastasesSABRSBRT

Identifiers

PMID37345175
PMCPMC10216793
OpenAlexW4377139019

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.