Evidence map›Paper›PMID 37345123›Full record

ArticleCancers2023

Long-Term Clinical Results of MR-Guided Stereotactic Body Radiotherapy of Liver Metastases.

Fabian Weykamp, Philipp Hoegen, Sebastian Regnery, Efthimios Katsigiannopulos, C Katharina Renkamp, Kristin Lang, Laila König, Elisabetta Sandrini, Eva Meixner, Carolin Rippke and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. MR-linac: role of artificial intelligence and automation.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Do We Have a Winner? Advocating for SBRT in HCC Management.Clinical and translational radiation oncology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Fabian WeykampDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.ORCID 0000-0003-1731-7090
Philipp HoegenDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Sebastian RegneryDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Efthimios KatsigiannopulosDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.ORCID 0000-0001-5795-1999
C Katharina RenkampDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Kristin LangDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Laila KönigDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Elisabetta SandriniDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Eva MeixnerDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.ORCID 0000-0001-7087-9581
Carolin RippkeDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Carolin BucheleDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Jakob LiermannDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Jürgen DebusDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Sebastian KlüterDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Juliane Hörner-RieberDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Heidelberg University · DEGerman Cancer Research Center · DE

Funding

German Research Foundation DFG DE 614/16-1
6 · The paper itself

Abstract

(1) Background: Magnetic-resonance (MR)-guided stereotactic body radiotherapy (SBRT) allows for ablative, non-invasive treatment of liver metastases. However, long-term clinical outcome data are missing. (2) Methods: Patients received MR-guided SBRT with a MRIdian Linac between January 2019 and October 2021 and were part of an ongoing prospective observational registry. Local hepatic control (LHC), distant hepatic control (DHC), progression free survival (PFS) and overall survival (OS) were estimated with the Kaplan-Meier method. Toxicity was documented according to CTCAE (v.5.0). (3) Results: Forty patients were treated for a total of 54 liver metastases (56% with online plan adaptation). Median prescribed dose was 50 Gy in five fractions equal to a biologically effective dose (BED) (alpha/beta = 10 Gy) of 100 Gy. At 1 and 2 years, LHC was 98% and 75%, DHC was 34% and 15%, PFS was 21% and 5% and OS was 83% and 57%. Two-year LHC was higher in case of BED > 100 Gy (100% vs. 57%; log-rank

Indexed as

adaptive radiotherapybiologically effective doseliver metastaseslocal controlMR-guidancestereotactic ablative body radiotherapy (SABR)stereotactic body radiotherapy (SBRT)

Identifiers

PMID37345123
PMCPMC10216397
OpenAlexW4377044071

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.