Evidence map›Paper›PMID 37345111›Full record

ReviewCancers2023

Tackling of Immunorefractory Tumors by Targeting Alternative Immune Checkpoints.

Dharmindra Dulal, Andrew Boring, David Terrero, Tiffany Johnson, Amit K Tiwari, Dayanidhi Raman

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Innate Immunity in Cancer Biology and Therapy.International journal of molecular sciences · 2023
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dharmindra DulalDepartment of Cell and Cancer Biology, University of Toledo Health Science Campus, Toledo, OH 43614, USA.
Andrew BoringDepartment of Cell and Cancer Biology, University of Toledo Health Science Campus, Toledo, OH 43614, USA.
David TerreroDepartment of Pharmacology & Experimental Therapeutics, College of Pharmacy & Pharmaceutical Sciences, University of Toledo Main Campus, Toledo, OH 43614, USA.
Tiffany JohnsonDepartment of Cell and Cancer Biology, University of Toledo Health Science Campus, Toledo, OH 43614, USA.
Amit K TiwariDepartment of Cell and Cancer Biology, University of Toledo Health Science Campus, Toledo, OH 43614, USA.ORCID 0000-0002-7427-7155
Dayanidhi RamanDepartment of Cell and Cancer Biology, University of Toledo Health Science Campus, Toledo, OH 43614, USA.ORCID 0000-0002-9340-1844
University of Toledo · US

Funding

Targeting eIF4A1 in drug-resistant breast cancer stem-like cellsR01CA258682 · NCI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI RAMAN, DAYANIDHI · 2022 to 2025
$2.5M
Targeting of eIF4A along with immunotherapy to overcome chemoresistanceR21CA256462 · NCI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI RAMAN, DAYANIDHI · 2022 to 2023
$394k
NCI NIH HHS R21 CA256462NIH HHS R211CA256462; R01CA258682
6 · The paper itself

Abstract

Physiologically, well known or traditional immune checkpoints (ICs), such as CTLA-4 and PD-1, are in place to promote tolerance to self-antigens and prevent generation of autoimmunity. In cancer, the ICs are effectively engaged by the tumor cells or stromal ells from the tumor microenvironment through expression of cognate ligands for the ICs present on the cell surface of CD8

Indexed as

CD8+ T lymphocytesCTLA-4immune checkpointsimmuno-refractory tumorsimmunosuppressionimmunotherapyLAG-3PD-1TIGITTIM-3VISTA

Identifiers

PMID37345111
PMCPMC10216651
OpenAlexW4377043852

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.