Evidence map›Paper›PMID 37345079›Full record

ArticleCancers2023

Genetic Ablation of the MET Oncogene Defines a Crucial Role of the HGF/MET Axis in Cell-Autonomous Functions Driving Tumor Dissemination.

Chiara Modica, Marco Cortese, Francesca Bersani, Andrea Maria Lombardi, Francesca Napoli, Luisella Righi, Riccardo Taulli, Cristina Basilico, Elisa Vigna

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. MET Oncogene Targeting for Cancer Immunotherapy.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Chiara ModicaCandiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, TO, Italy.ORCID 0000-0002-7000-5216
Marco CorteseCandiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, TO, Italy.ORCID 0000-0003-0399-9094
Francesca BersaniDepartment of Oncology, University of Torino, 10043 Orbassano, TO, Italy.ORCID 0000-0002-0343-7078
Andrea Maria LombardiDepartment of Oncology, University of Torino, 10043 Orbassano, TO, Italy.ORCID 0009-0008-5076-1621
Francesca NapoliDepartment of Oncology, University of Torino, 10043 Orbassano, TO, Italy.ORCID 0000-0002-9745-998X
Luisella RighiDepartment of Oncology, University of Torino, 10043 Orbassano, TO, Italy.ORCID 0000-0002-8927-204X
Riccardo TaulliDepartment of Oncology, University of Torino, 10043 Orbassano, TO, Italy.
Cristina BasilicoCandiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, TO, Italy.ORCID 0000-0002-8722-5485
Elisa VignaCandiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, TO, Italy.ORCID 0000-0001-9787-5732
University of Turin · ITCandiolo Cancer Institute · IT

Funding

Associazione Italiana Ricerca sul Cancro (AIRC) IG 2021 - ID 25978 - PI: RTItalian Association for Cancer Research 5 per Mille 2018 - ID 21052Ministero della Salute Ricerca Corrente 2022
6 · The paper itself

Abstract

Cancer cell dissemination is sustained by cell-autonomous and non-cell-autonomous functions. To disentangle the role of HGF (Hepatocyte Growth Factor) and MET ligand/receptor axis in this complex process, we genetically knocked out the MET gene in cancer cells in which MET is not the oncogenic driver. In this way, we evaluated the contribution of the HGF/MET axis to cancer cell dissemination independently of its direct activities in cells of the tumor microenvironment. The lack of MET expression in MET

Indexed as

HGFinvasionMETmetastasispancreatic cancers

Identifiers

PMID37345079
PMCPMC10216813
OpenAlexW4381598194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.