Evidence map›Paper›PMID 37344788›Full record

ArticleBMC genomic data2023

Association between SUMF1 polymorphisms and COVID-19 severity.

Shaohui Liang, Huixia Gao, Tongxin He, Li Li, Xin Zhang, Lei Zhao, Jie Chen, Yanyan Xie, Jie Bao, Yong Gao and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomic data, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. The Genetics behind Sulfation: Impact on Airway Remodeling.Journal of personalized medicine · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Shaohui Liang *Department of Respiratory, Hebei Chest Hospital, Shijiazhuang, 050000, Hebei, China.
Huixia Gao *Department of Laboratory Medicine, The Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, 050021, Hebei, China.
Tongxin He *College of Plant Protection, Hunan Agricultural University, Changsha, 410128, Hunan, China.
Li LiIntensive Care Unit, The Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, 050021, Hebei, China.
Xin ZhangDepartment of Tuberculosis, The Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, 050021, Hebei, China.
Lei ZhaoThe Second Internal Medicine, The Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, 050021, Hebei, China.
Jie ChenGraduate School of Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Yanyan XieGraduate School of Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Jie BaoDepartment of Respiratory, Hebei Chest Hospital, Shijiazhuang, 050000, Hebei, China.
Yong GaoDepartment of Respiratory, Hebei Chest Hospital, Shijiazhuang, 050000, Hebei, China.
Erhei DaiDepartment of Laboratory Medicine, The Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, 050021, Hebei, China. daieh2008@126.com.
Yuling WangDepartment of Tuberculosis, The Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, 050021, Hebei, China. 1149497466@qq.com.
Hebei Medical University · CNHospital of Hebei Province · CNHunan Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvidence shows that genetic factors play important roles in the severity of coronavirus disease 2019 (COVID-19). Sulfatase modifying factor 1 (SUMF1) gene is involved in alveolar damage and systemic inflammatory response. Therefore, we speculate that it may play a key role in COVID-19.

resultsWe found that rs794185 was significantly associated with COVID-19 severity in Chinese population, under the additive model after adjusting for gender and age (for C allele = 0.62, 95% CI = 0.44-0.88, P = 0.0073, logistic regression). And this association was consistent with this in European population Genetics Of Mortality In Critical Care (GenOMICC: OR for C allele = 0.94, 95% CI = 0.90-0.98, P = 0.0037). Additionally, we also revealed a remarkable association between rs794185 and the prothrombin activity (PTA) in subjects (P = 0.015, Generalized Linear Model).

conclusionsIn conclusion, our study for the first time identified that rs794185 in SUMF1 gene was associated with the severity of COVID-19.

Indexed as

COVID-19SulfatasesHumansOxidoreductases Acting on Sulfur Group DonorsPolymorphism, GeneticOxidoreductases Acting on Sulfur Group DonorsSulfatasesSUMF1 protein, humanCOVID-19Multiple sclerosisrs794185SUMF1

Identifiers

PMID37344788
PMCPMC10283310
OpenAlexW4381599167

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.