Evidence map›Paper›PMID 37344684›Full record

ArticleNPJ digital medicine2023

Deep-learning-enabled brain hemodynamic mapping using resting-state fMRI.

Xirui Hou, Pengfei Guo, Puyang Wang, Peiying Liu, Doris D M Lin, Hongli Fan, Yang Li, Zhiliang Wei, Zixuan Lin, Dengrong Jiang and 11 more

Open access · goldAbstract read
In one paragraph

Article in NPJ digital medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 1 country.

Xirui HouDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Pengfei GuoDepartment of Computer Science, Johns Hopkins University, Baltimore, MD, USA.
Puyang WangDepartment of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-2657-6051
Peiying LiuDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Doris D M LinThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-6001-2383
Hongli FanDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yang LiThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Zhiliang WeiThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Zixuan LinThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Dengrong JiangThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jin JinDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Catherine KellyDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jay J PillaiThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Judy HuangDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Marco C PinhoDepartment of Radiology, UT Southwestern Medical Center, Dallas, TX, USA.
Binu P ThomasDepartment of Radiology, UT Southwestern Medical Center, Dallas, TX, USA.
Babu G WelchDepartment of Neurologic Surgery, UT Southwestern Medical Center, Dallas, TX, USA.
Denise C ParkCenter for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA.
Vishal M PatelDepartment of Computer Science, Johns Hopkins University, Baltimore, MD, USA.
Argye E HillisDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Hanzhang LuDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA. hanzhang.lu@jhu.edu.ORCID http://orcid.org/0000-0003-3871-1564
Johns Hopkins University · USKennedy Krieger Institute · USSouthwestern Medical Center · USThe University of Texas at Dallas · USUniversity of Maryland, Baltimore · US

Funding

Neural Basis of Lexical Deficits in Hyperacute StrokeR01DC005375 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI Argye E. Hillis · 2002 to 2026
$11.8M
Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI S. Ali Fatemi, Bradley L Schlaggar · 2020 to 2026
$9.9M
TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
Dallas Lifespan Brain Study-Wave 3: Neurodegeneration & Resilience in CognitionRF1AG006265 · NIA · UNIVERSITY OF TEXAS DALLAS · PI PARK, DENISE CORTIS · 2017 to 2019
$7.1M
The Neural Basis of Impaired Affective Prosody in Alzheimer's Disease and Frontotemporal DegenerationR01DC015466 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI HILLIS, ARGYE E. · 2017 to 2021
$3.5M
An integrated vascular MR imaging suite in brain diseasesR01NS106702 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2018 to 2022
$2.7M
Validation of small vessel vascular contributions to cognitive impairment and dementia (VCID) biomarkersUF1NS100588 · NINDS · JOHNS HOPKINS UNIVERSITY · PI ALBERT, MARILYN S., LU, HANZHANG · 2021 to 2021
$2.6M
Non-contrast MR imaging of blood-brain-barrier permeability in Alzheimer's diseaseR01AG064792 · NIA · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2020 to 2023
$2.6M
Blood-brain barrier dysfunction in Alzheimer's disease: from humans to animal modelsRF1AG071515 · NIA · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2021 to 2021
$2.4M
MR fingerprinting (MRF) perfusion imaging in cerebral vascular diseaseR01NS106711 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2018 to 2022
$2.2M
State of the Art 3T Research ScannerS10OD021648 · OD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2016 to 2016
$2.0M
Multi-ethnic risk prediction for complex human diseases integrating multi-source genetic and non-genetic informationR00HG012223 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI JIN, JIN · 2023 to 2025
$727k
NHGRI NIH HHS R00 HG012223NIA NIH HHS R01 AG064792NIA NIH HHS RF1 AG006265NIA NIH HHS RF1 AG071515NIBIB NIH HHS P41 EB031771NICHD NIH HHS P50 HD103538NIDCD NIH HHS R01 DC005375NIDCD NIH HHS R01 DC015466NIH HHS S10 OD021648NINDS NIH HHS R01 NS106702NINDS NIH HHS R01 NS106711NINDS NIH HHS UF1 NS100588
6 · The paper itself

Abstract

Cerebrovascular disease is a leading cause of death globally. Prevention and early intervention are known to be the most effective forms of its management. Non-invasive imaging methods hold great promises for early stratification, but at present lack the sensitivity for personalized prognosis. Resting-state functional magnetic resonance imaging (rs-fMRI), a powerful tool previously used for mapping neural activity, is available in most hospitals. Here we show that rs-fMRI can be used to map cerebral hemodynamic function and delineate impairment. By exploiting time variations in breathing pattern during rs-fMRI, deep learning enables reproducible mapping of cerebrovascular reactivity (CVR) and bolus arrival time (BAT) of the human brain using resting-state CO

Identifiers

PMID37344684
PMCPMC10284915
OpenAlexW4381548497

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.