ArticleNature2023
Signalling by senescent melanocytes hyperactivates hair growth.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
12.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 42 citations in OpenAlex.
- Efficacy and Safety of Rb-bFGF in Hair Transplantation: A Prospective and Comparative Study.Journal of cosmetic dermatology · 2025Trial
- Aging of hair follicle stem cells and their niche: mechanisms and regenerative therapeutic strategies.Cell communication and signaling : CCS · 2026Review
- Skin aging: mechanisms, evaluation, and rejuvenation.The EMBO journal · 2026Review
- Cardiovascular ageing: hallmarks, signaling pathways, diseases and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Recycling senescent cell lipids for targeted senotherapy.Nature communications · 2026Article
- SPP1+ Macrophages and the Orchestration of Spatially Organized Immunosuppression in Cancer.Biomedicines · 2026Review
- Single-cell transcriptomic profiling of halo nevi and normal nevi reveals CD8Frontiers in immunology · 2026Article
- Cold Atmospheric Plasma-Activated In Situ Hydrogel Induces Hair Regeneration Via Immune Microenvironment Remodeling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Synergistic interplay between UV and urban particulate matter exposure induces melanocyte senescence and contributes to human skin aging.Scientific reports · 2025Article
- Androgenetic alopecia.Nature reviews. Disease primers · 2025Review
- Uncovering hidden protein modifications with native top-down mass spectrometry.Nature methods · 2025Article
- The Skin Microenvironment: A Dynamic Regulator of Hair Follicle Development, Cycling and Disease.Biomolecules · 2025Review
- Regenerative Hair Pigmentation via Skin Organoids: Adaptive Patterning Mediated by Collagen VI and Semaphorin 3C.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Escape from TGF-β-induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells.Molecular oncology · 2025Article
- CD44 signaling in skin wound healing and regeneration.Journal of translational medicine · 2025Review
- Osteopontin de-escalates the foreign body response.Nature biomedical engineering · 2025Article
- Osteopontin attenuates the foreign-body response to silicone implants.Nature biomedical engineering · 2025Article
- Evolution of long scalp hair in humans.The British journal of dermatology · 2025Review
- Hair regrowth in alopecia areata and re-pigmentation in vitiligo in response to treatment: Commonalities and differences.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
50 authors at 10 institutions in 9 countries.
Xiaojie WangDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA. xiaojiw2@uci.edu.ORCID 0000-0003-4817-5830
Raul RamosDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.ORCID 0000-0003-0853-1028
Anne Q PhanGlycobiology Research and Training Center, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-5195-7185
Kosuke YamagaDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.
Jessica L FlesherDepartment of Biological Chemistry, University of California, Irvine, CA, USA.ORCID 0000-0002-3808-7661
Shan JiangDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.
Ji Won OhDepartment of Anatomy, Yonsei University College of Medicine, Seoul, Korea.
Suoqin JinDepartment of Mathematics, University of California, Irvine, CA, USA.ORCID 0000-0002-5131-0215
Sohail JahidDepartment of Biological Chemistry, University of California, Irvine, CA, USA.
Chen-Hsiang KuanDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.ORCID 0000-0001-5599-7125
Truman Kt NguyenDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.
Heidi Y LiangDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.
Nitish Udupi ShettigarDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.ORCID 0000-0002-6888-6368
Renzhi HouDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.
Kevin H TranDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.
Andrew NguyenDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.
Kimberly N VuDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.ORCID 0000-0003-0389-0347
Jennie L PhungDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.
Jonard P IngalDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.
Katelyn M LevittDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.
Xiaoling CaoDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.ORCID 0000-0003-4993-8385
Yingzi LiuDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.ORCID 0000-0002-8704-4756
Zhili DengDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Nobuhiko TaguchiDepartment of Tissue and Organ Development, Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu, Japan.ORCID 0000-0002-1787-7330
Vanessa M ScarfoneSue and Bill Gross Stem Cell Research Center, University of California, Irvine, CA, USA.
Guangfang WangSue and Bill Gross Stem Cell Research Center, University of California, Irvine, CA, USA.
Kara Nicole PaolilliSue and Bill Gross Stem Cell Research Center, University of California, Irvine, CA, USA.
Xiaoyang WangSue and Bill Gross Stem Cell Research Center, University of California, Irvine, CA, USA.
Christian F Guerrero-JuarezDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.ORCID 0000-0002-6245-6412
Ryan T DavisDepartment of Physiology and Biophysics, University of California, Irvine, CA, USA.
Elyse Noelani GreenbergDepartment of Biological Chemistry, University of California, Irvine, CA, USA.
Rolando Ruiz-VegaDepartment of Biological Chemistry, University of California, Irvine, CA, USA.
Priya VasudevaDepartment of Biological Chemistry, University of California, Irvine, CA, USA.
Rabi MuradDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.
Lily Halida Putri WidyastutiSue and Bill Gross Stem Cell Research Center, University of California, Irvine, CA, USA.
Hye-Lim LeeDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.
Kevin J McElweeCentre for Skin Sciences, University of Bradford, Bradford, UK.ORCID 0000-0003-1020-3832
Alain-Pierre GadeauUniversity of Bordeaux, INSERM U1034, Adaptation cardiovasculaire à l'ischémie, Pessac, France.ORCID 0000-0003-1312-6481
Devon A LawsonDepartment of Physiology and Biophysics, University of California, Irvine, CA, USA.ORCID 0000-0003-1692-0517
Bogi AndersenSue and Bill Gross Stem Cell Research Center, University of California, Irvine, CA, USA.
Ali MortazaviDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.ORCID 0000-0002-4259-6362
Zhengquan YuState Key Laboratory of Farm Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Qing NieDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.ORCID 0000-0002-8804-3368
Takahiro KunisadaDepartment of Tissue and Organ Development, Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu, Japan.
Michael KarinLaboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Jan TuckermannInstitute for Comparative Molecular Endocrinology (CME), University of Ulm, Helmholtzstrasse 8/1, Ulm, Germany.ORCID 0000-0003-3691-275X
Jeffrey D EskoGlycobiology Research and Training Center, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Anand K GanesanDepartment of Biological Chemistry, University of California, Irvine, CA, USA.
Ji LiDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0003-0931-5562
Maksim V PlikusDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA. plikus@uci.edu.ORCID 0000-0002-8845-2559
University of California, Irvine · USCentral South University · CNUniversity of California San Diego · USGifu University · JPChina Agricultural University · CNNational Taiwan University · TWUniversität Ulm · DEUniversité de Bordeaux · FRUniversity of Bradford · GBYonsei University · KR
Funding
Shared Resource Core: Single Cell AnalysisU54CA217378 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LOWENGRUB, JOHN · 2018 to 2022
$9.7MTranscriptional Co-Regulators in EpidermisR01AR044882 · NIAMS · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI Bogi Andersen · 1998 to 2026
$9.0MCARCINOGENESIST32CA009054 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI EDINGER, AIMEE L, FRUMAN, DAVID ALEXANDER · 1985 to 2025
$8.6MUCI P30 Skin Center Systems Biology CoreP30AR075047 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ANDERSEN, BOGI, GANESAN, ANAND K · 2019 to 2025
$5.1MMultiscale Models of Wound Cell Plasticity for RegenerationU01AR073159 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAI, XING, NIE, QING · 2018 to 2022
$3.5MTissue Size and Precision Control in Growing Hair FolliclesR01AR079150 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Qing Nie, Maksim V Plikus · 2022 to 2026
$2.7MLeveraging immune-fibroblast interactions for biomaterial induced skin regenerationR01AR079470 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SCUMPIA, PHILIP · 2021 to 2025
$2.6MIdentifying Therapeutic Targets for Stage III MelanomaR01CA244571 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI GANESAN, ANAND K · 2020 to 2024
$2.4MInterdisciplinary Training Program in Skin BiologyT32AR080622 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Bogi Andersen, Anand K Ganesan · 2022 to 2026
$909kEnhancement of wound healing and regeneration through heparan sulfate deficiencyR61AR073031 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ESKO, JEFFREY D · 2017 to 2018
$753kEnhancement of wound healing and regeneration through heparan sulfate deficiencyR33AR073031 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ESKO, JEFFREY D · 2019 to 2019
$392kBlastema-independent Mechanism for Regeneration in SalamandersR21AR078939 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GARDINER, DAVID M., PLIKUS, MAKSIM V · 2022 to 2023
$380kNCI NIH HHS R01 CA244571NCI NIH HHS T32 CA009054NCI NIH HHS U54 CA217378NIAMS NIH HHS P30 AR075047NIAMS NIH HHS R01 AR044882NIAMS NIH HHS R01 AR079150NIAMS NIH HHS R01 AR079470NIAMS NIH HHS R21 AR078939NIAMS NIH HHS R33 AR073031NIAMS NIH HHS R61 AR073031NIAMS NIH HHS T32 AR080622NIAMS NIH HHS U01 AR073159
Abstract
Niche signals maintain stem cells in a prolonged quiescence or transiently activate them for proper regeneration
Indexed as
HairMelanocytesSignal TransductionAnimalsHair FollicleHyaluronan ReceptorsMiceNevusOsteopontinStem CellsCd44 protein, mouseHyaluronan ReceptorsOsteopontin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.