Evidence map›Paper›PMID 37344598›Full record

ArticleNature2023

Structural basis of mitochondrial protein import by the TIM23 complex.

Sue Im Sim, Yuanyuan Chen, Diane L Lynch, James C Gumbart, Eunyong Park

Open access · greenAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.

  1. Pooled it
  2. Regulation of cellular proteostasis via mitochondrial protein import.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Dynamic disorder is crucial for mitochondrial protein import.Protein science : a publication of the Protein Society · 2026
    Review
  10. Review
  11. Proteolytic control of mitochondrial protein translocases.Protein science : a publication of the Protein Society · 2026
    Review
  12. Review
  13. Functions of J-domain proteins in mitochondrial protein biogenesis.Protein science : a publication of the Protein Society · 2026
    Review
  14. Article
  15. In and out of the mitochondrial intermembrane space.Protein science : a publication of the Protein Society · 2026
    Review
  16. Mitochondrial presequences are more than just address labels.Protein science : a publication of the Protein Society · 2026
    Review
  17. Article
  18. Mechanisms and regulation of the Hsp70 chaperone network.Nature reviews. Molecular cell biology · 2026
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Sue Im Sim *Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.ORCID 0000-0003-3560-101X
Yuanyuan Chen *Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
Diane L LynchSchool of Physics, Georgia Institute of Technology, Atlanta, GA, USA.
James C GumbartSchool of Physics, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0002-1510-7842
Eunyong ParkDepartment of Molecular and Cell Biology, University of California, Berkeley, CA, USA. eunyong_park@berkeley.edu.ORCID 0000-0003-2994-5174
Georgia Institute of Technology · USQB3 · USUniversity of California, Berkeley · US

Funding

MOLECULAR BIOPHYSICS TRAINING GRANTT32GM008295 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HURLEY, JAMES H, WEMMER, DAVID E · 1989 to 2022
$8.1M
Dynamic characterization of outer-membrane-protein biogenesis by the BAM and TAM complexesR01GM123169 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI GUMBART, JAMES C. · 2017 to 2021
$1.4M
NIGMS NIH HHS R01 GM123169NIGMS NIH HHS T32 GM008295
6 · The paper itself

Abstract

Mitochondria import nearly all of their approximately 1,000-2,000 constituent proteins from the cytosol across their double-membrane envelope

Indexed as

MitochondriaMitochondrial Precursor Protein Import Complex ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsCryoelectron MicroscopyMembrane ProteinsProtein TransportMembrane ProteinsMgr2 protein, S cerevisiaeMitochondrial Precursor Protein Import Complex ProteinsSaccharomyces cerevisiae ProteinsTIM17 protein, S cerevisiae

Identifiers

PMID37344598
PMCPMC11495887
OpenAlexW4381480938

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.