ArticleNature2023
Injury prevents Ras mutant cell expansion in mosaic skin.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 36 citations in OpenAlex.
- Reflecting on 25 years of cancer research: transformative advances and unmet expectations.Nature reviews. Cancer · 2026Article
- Chemically induced skin tumors arise from long-lived stem cells of the upper hair follicle.Science (New York, N.Y.) · 2026Article
- Stem cells as an essential mediator of the exercise-tumorigenesis link.Nature reviews. Cancer · 2026Review
- Article
- Stem cell control and cancer initiation by an autocrine, injury-activated Igf complex.bioRxiv : the preprint server for biology · 2026Article
- Mosaic partial epidermal reprogramming remodels neighbors and niches to refine skin homeostasis and repair.Nature communications · 2026Article
- Broad-Spectrum RAS Inhibition in Pancreatic Ductal Adenocarcinoma: Mechanistic Advances and Therapeutic Promise.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Spatiotemporally controlled delivery of biological effectors from nanofiber scaffolds accelerates skin wound healing in porcine models.Science advances · 2025Article
- Mechanisms of cellular fitness and cell competition: Towards an integrated view.Current opinion in cell biology · 2025Review
- Mechanistic Foundations of KRAS-Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Long-Term Latency of Highly Mutated Cells in Normal Mouse Skin Is Reversed by Exposure to Tumor Promoters and Chronic Tissue Damage.Cancer discovery · 2025Article
- Clonal effects of thebioRxiv : the preprint server for biology · 2025Article
- Stromal KITL/SCF Maintains Pancreas Tissue Homeostasis and Restrains Tumor Progression.Cancer discovery · 2025Article
- Single-cell genotyping and transcriptomic profiling of mosaic focal cortical dysplasia.Nature neuroscience · 2025Article
- Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation.Cell stem cell · 2025Article
- The evolving landscape of laser-based skin cancer prevention.Lasers in medical science · 2025Review
- Commensal papillomavirus immunity preserves the homeostasis of highly mutated normal skin.Cancer cell · 2025Article
- Imperfect wound healing sets the stage for chronic diseases.Science (New York, N.Y.) · 2024Review
- An expanded view of cell competition.Development (Cambridge, England) · 2024Review
- A New Strategy to Inhibit Scar Formation by Accelerating Normal Healing Using Silicate Bioactive Materials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Sara GalliniDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-6945-093X
Karl Annusver *Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Nur-Taz Rahman *Bioinformatics Support Program, Cushing/Whitney Medical Library, Yale School of Medicine, New Haven, CT, USA.
David G GonzalezDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.
Sangwon YunDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-1156-8094
Catherine Matte-MartoneDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-0633-1559
Tianchi XinDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.
Elizabeth LathropDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.
Kathleen C SuozziDermatologic Surgery, Yale School of Medicine, New Haven, CT, USA.
Maria KasperDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden. maria.kasper@ki.se.ORCID 0000-0002-6117-2717
Valentina GrecoDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA. valentina.greco@yale.edu.ORCID 0000-0002-6492-4603
Yale University · USKarolinska Institutet · SEWhitney Museum of American Art · USYale Cancer Center · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MLive Imaging of Skin RegenerationR01AR063663 · NIAMS · YALE UNIVERSITY · PI Valentina Greco · 2012 to 2026
$7.7MUnderstanding Skin Tissue Repair in Live MammalsR01AR072668 · NIAMS · YALE UNIVERSITY · PI Valentina Greco · 2018 to 2026
$6.2MDefining the role of mutational burden in sustaining normal homeostasis during agingDP1AG066590 · NIA · YALE UNIVERSITY · PI GRECO, VALENTINA · 2019 to 2023
$5.9MNormal stem cells and their transition to disease in the skinR01AR067755 · NIAMS · YALE UNIVERSITY · PI GRECO, VALENTINA · 2016 to 2020
$2.2MNCATS NIH HHS UL1 TR001863NIAMS NIH HHS R01 AR063663NIAMS NIH HHS R01 AR067755NIAMS NIH HHS R01 AR072668NIA NIH HHS DP1 AG066590
Abstract
Healthy skin is a mosaic of wild-type and mutant clones
Indexed as
Cell ProliferationGenes, rasMosaicismMutationras ProteinsSkinCell CycleCyclin-Dependent Kinase Inhibitor p21ErbB ReceptorsCyclin-Dependent Kinase Inhibitor p21ErbB Receptorsras Proteins
Identifiers
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.