Evidence map›Paper›PMID 37344567›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2023

Associations between physical activity and autonomic function during deep breathing test: the Swedish CArdioPulmonary bioImage Study (SCAPIS).

Ensieh Memarian, Isabella Kharraziha, Viktor Hamrefors, Pyotr G Platonov, Örjan Ekblom, Anders Gottsäter, Gunnar Engström

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Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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  3. Neurocardiology - from basics to clinic.World journal of cardiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ensieh MemarianDepartment of Clinical Sciences, Malmö, Internal Medicine Research Group, Skåne University Hospital, Lund University, Jan Waldenströms gata 15, 5th Floor, S-20502, Malmo, Sweden. ensieh.memarian@med.lu.se.ORCID 0000-0002-8214-917X
Isabella KharrazihaDepartment of Clinical Sciences, Malmö, Internal Medicine Research Group, Skåne University Hospital, Lund University, Jan Waldenströms gata 15, 5th Floor, S-20502, Malmo, Sweden.
Viktor HamreforsDepartment of Clinical Sciences, Malmö, Internal Medicine Research Group, Skåne University Hospital, Lund University, Jan Waldenströms gata 15, 5th Floor, S-20502, Malmo, Sweden.
Pyotr G PlatonovDepartment of Cardiology, Clinical Sciences Lund, Lund University, Lund, Sweden.
Örjan EkblomDepartment of Physical Activity and Health, The Swedish School of Sport and Health Sciences, Stockholm, Sweden.
Anders GottsäterDepartment of Clinical Sciences, Malmö, Internal Medicine Research Group, Skåne University Hospital, Lund University, Jan Waldenströms gata 15, 5th Floor, S-20502, Malmo, Sweden.
Gunnar EngströmDepartment of Clinical Sciences, Malmö, Internal Medicine Research Group, Skåne University Hospital, Lund University, Jan Waldenströms gata 15, 5th Floor, S-20502, Malmo, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe deep breathing test (DBT) is a sensitive test of cardiovagal function. The aim of this study was to explore associations between physical activity and sedentary time, measured by accelerometer, and autonomic function, using DBT.

methodsIn the Swedish Cardio-Pulmonary bioImage Study, men and women aged 50-64 were randomly invited from the general population. A total of 4325 subjects who underwent DBT and assessment of physical activity and sedentary time by accelerometery were included. ECG files from 1-min DBT were used to calculate measures of respiratory sinus arrhythmia [RSA; expiration-inspiration (E-I) difference and E/I ratio], heart rate variability [HRV; root mean square of successive differences (RMSSD), standard deviation of heart rates and mean circular resultant]. Low RSA and HRV was defined as the lowest 10% in the population.

resultsFor accelerometer-assessed physical activity, there were significant associations between high percentage of sedentary time and low E/I (p < 0.01), and low RMSSD (p < 0.01) in an age- and sex-adjusted model, and between percentage of sedentary time and low RMSSD (p = 0.04) in a risk factor-adjusted model. Low RMSSD was less common in those with a high percentage of moderate to vigorous physical activity (p = 0.04, after risk-factor adjustment). These associations became non-significant when further adjusting for heart rate.

conclusionWe report associations between degree of physical activity and indices of autonomic dysfunction in a large population. The relationships were no longer significant after adjustments for heart rate, indicating that the relationship between physical activity and cardiovagal function partly is accounted for by reduced heart rate.

Indexed as

HeartRespiratory Sinus ArrhythmiaExerciseFemaleHeart RateHumansMaleMiddle AgedSwedenAccelerometerAutonomic functionCardiovagal functionDeep breathing testHeart rate variationPhysical activity

Identifiers

PMID37344567
PMCPMC10439237

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.