Evidence map›Paper›PMID 37344474›Full record

ArticleNPJ breast cancer2023

A phase Ib trial of pembrolizumab plus paclitaxel or flat-dose capecitabine in 1st/2nd line metastatic triple-negative breast cancer.

David B Page, Joanna Pucilowska, Brie Chun, Isaac Kim, Katherine Sanchez, Nicole Moxon, Staci Mellinger, Yaping Wu, Yoshinobu Koguchi, Valerie Conrad and 18 more

Open access · goldAbstract read
In one paragraph

Article in NPJ breast cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 6 citations in OpenAlex.

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  10. Expert consensus on the clinical application of immunotherapy in breast cancer: 2024.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 2 institutions in 1 country.

David B PageEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA. david.page2@providence.org.ORCID http://orcid.org/0000-0001-9264-4628
Joanna PucilowskaEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Brie ChunEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.ORCID http://orcid.org/0000-0001-7520-8365
Isaac KimEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Katherine SanchezEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Nicole MoxonEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.ORCID http://orcid.org/0000-0003-4376-9082
Staci MellingerEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Yaping WuEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Yoshinobu KoguchiEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.ORCID http://orcid.org/0000-0002-5733-5755
Valerie ConradEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
William L RedmondEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.ORCID http://orcid.org/0000-0002-2572-1731
Maritza MartelEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Zhaoyu SunEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Mary B CampbellEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Alison ConlinEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Anupama AchesonEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Reva BashoCedars Sinai Medical Center, Los Angeles, CA, USA.
Philomena McAndrewCedars Sinai Medical Center, Los Angeles, CA, USA.
Mary El-MasryCedars Sinai Medical Center, Los Angeles, CA, USA.
Dorothy ParkCedars Sinai Medical Center, Los Angeles, CA, USA.
Laura BennettsEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Robert S SeitzOncocyte Corporation, Irving, CA, USA.
Tyler J NielsenOncocyte Corporation, Irving, CA, USA.ORCID http://orcid.org/0000-0002-9576-2838
Kimberly McGregorOncocyte Corporation, Irving, CA, USA.
Venkatesh RajamanickamEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Brady BernardEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Walter J UrbaEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Heather L McArthurCedars Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-0201-3871
Providence Portland Medical Center · USCedars-Sinai Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemoimmunotherapy with anti-programmed cell death 1/ligand 1 and cytotoxic chemotherapy is a promising therapeutic modality for women with triple-negative breast cancer, but questions remain regarding optimal chemotherapy backbone and biomarkers for patient selection. We report final outcomes from a phase Ib trial evaluating pembrolizumab (200 mg IV every 3 weeks) with either weekly paclitaxel (80 mg/m

Identifiers

PMID37344474
PMCPMC10284878
OpenAlexW4381597419

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.