Evidence map›Paper›PMID 37344425›Full record

ArticleInternal medicine (Tokyo, Japan)2024

Clinicopathologic Features of Adult-onset Still's Disease Complicated by Severe Liver Injury.

Miho Kurokawa, Tomonobu Hioki, Tomomi Aoyagi, Motoi Takahashi, Koji Imoto, Takeshi Goya, Masatake Tanaka, Motoyuki Kohjima, Yoshihiro Ogawa

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Miho KurokawaDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Japan.
Tomonobu HiokiDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Japan.
Tomomi AoyagiDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Japan.
Motoi TakahashiDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Japan.
Koji ImotoDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Japan.
Takeshi GoyaDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Japan.
Masatake TanakaDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Japan.
Motoyuki KohjimaDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Japan.
Yoshihiro OgawaDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Japan.
Kyushu University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder. Severe liver injury has rarely been reported, although liver enzyme elevation is a common complication of AOSD. We herein report four cases of relapsed AOSD with severe liver disorder by tapering or terminating corticosteroids. Liver specimens revealed robust infiltration of inflammatory cells throughout the lobule, especially cluster of differentiation (CD) 8-positive cells. Relapsed AOSD was refractory to corticosteroid reintroduction and required immunosuppressants. Severe liver injury with AOSD is pathologically characterized by extensive lobular infiltration of CD8-positive cells, and we should consider additive immunosuppressive agents on corticosteroids for treatment.

Indexed as

Still's Disease, Adult-OnsetAdrenal Cortex HormonesAdultHumansImmunosuppressive AgentsLiverAdrenal Cortex HormonesImmunosuppressive Agentsacute liver injuryadult-onset Still's diseaseCD8-positive cells

Identifiers

PMID37344425
PMCPMC10937138
OpenAlexW4381433504

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.