Evidence map›Paper›PMID 37344326›Full record

ArticleUrologic oncology2023

Racial differences in survival for early stage (T1) penile cancer: Analysis from the SEER database.

Nellowe C Candelario, Elizabeth Molina, Maria T Bourlon, Simon P Kim, Elizabeth R Kessler, Philippe E Spiess, Thomas W Flaig

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Urologic oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Nellowe C CandelarioDivision of Medical Oncology, University of Colorado Cancer Center Anschutz Medical Campus, Aurora, CO.
Elizabeth MolinaDivision of Medical Oncology, University of Colorado Cancer Center Anschutz Medical Campus, Aurora, CO.
Maria T BourlonHemato-Oncology Deparment, Urologic Oncology Clinic, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Simon P KimDivision of Urology, University of Colorado Cancer Center Anschutz Medical Campus, Aurora, CO.
Elizabeth R KesslerDivision of Medical Oncology, University of Colorado Cancer Center Anschutz Medical Campus, Aurora, CO.
Philippe E SpiessDepartment of GU Oncology and Tumor Biology, Moffitt Cancer Center, Tampa, FL.
Thomas W FlaigDivision of Medical Oncology, University of Colorado Cancer Center Anschutz Medical Campus, Aurora, CO. Electronic address: Thomas.Flaig@CUAnschutz.edu.
University of Colorado Cancer Center · USInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MXMoffitt Cancer Center · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
NCI NIH HHS P30 CA046934
6 · The paper itself

Abstract

backgroundPenile cancer accounts for less than 1% of male cancers in the United States. Localized disease, particularly T1 tumors are potentially curable with local therapy. We present the racial differences in survival outcomes for T1, penile cancer from the SEER database.

methodsFrom 2004 to 2016 all men with T1, N0, M0 penile cancer in the SEER-18 database were included. Kaplan-Meier analysis and multivariable Cox-Regression analysis were conducted to investigate prognostic variables for cancer specific survival (CSS).

resultsA total of 4,406 men were identified with penile cancer; 1,941 men had T1 disease. The Kaplan-Meier (KM) analysis showed those with primary site surgery had better 5-year CSS compared to those without primary site surgery (P <.0001) and a significant difference in CSS based on race (P= 0.0078). On multivariable analysis, Hispanic individuals had worse CSS (HR 1.92; P = 0.0057) compared to the White men. Black men were also found to have a poor CSS however this was not statistically significant (HR 1.53, P = 0.118). Men with penile cancer who had either penectomy (HR 0.45; P = 0.006) or penile preservation surgery (HR 0.25; P< 0.001) had improved CSS.

conclusionRacial disparities in CSS exist among men with in early-stage penile cancer. KM analysis showed significant differences in CSS by race and in those receiving primary site surgery. On multivariable analysis, the CSS is worse in Hispanic compared to White men. There is a trend towards worse CSS in Black men however this was not statistically significant.

Indexed as

Penile NeoplasmsBlack or African AmericanHispanic or LatinoHumansMaleNeoplasm StagingPrognosisRace FactorsSEER ProgramUnited StatesWhiteHealthcare disparitiesPenile cancerPenile neoplasmRaceTumor Staging

Identifiers

PMID37344326
PMCPMC10658609
OpenAlexW4381383445

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.