ArticleSleep health2023
Is there an association between daytime napping, cognitive function, and brain volume? A Mendelian randomization study in the UK Biobank.
Article in Sleep health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Research advances in physical activity and insomnia: a bibliometric and thematic evolution analysis.Frontiers in psychiatry · 2026Pooled it
- Pooled it
- Insomnia-Driven Hippocampal Atrophy: Evidence From Bidirectional Mendelian Randomization.Health science reports · 2026Article
- Sleep and neurocognitive performance in middle-aged Latina women in a rural agricultural community: insights from the CHAMACOS Maternal Cognition Study.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Can we predict sleep health based on brain features? A large-scale machine learning study using the UK Biobank.Brain communications · 2026Article
- Multiple Health Outcomes of Daytime Napping: A Comprehensive Umbrella Review.Public health reviews · 2026Review
- Associations of afternoon naps with progression of advanced cardiovascular-kidney-metabolic syndrome among Chinese adults aged 45 years and above.Scientific reports · 2025Article
- Timing and intraindividual variability of daytime napping and Alzheimer's disease in older adults.Communications medicine · 2025Article
- Daytime Napping in Adults: Benefits or Risks? Insights from Mendelian Randomization Studies.Current sleep medicine reports · 2025Article
- Napping and Obesity in Adults - What do we Know?Current diabetes reports · 2024Review
- Prediction of Mild Cognitive Impairment Status: Pilot Study of Machine Learning Models Based on Longitudinal Data From Fitness Trackers.JMIR formative research · 2024Article
- Is napping in older adults problematic or productive? The answer may lie in the reason they nap.Sleep · 2024Article
- Sleep Characteristics and Risk of Stroke and Dementia: An Observational and Mendelian Randomization Study.Neurology · 2024Observational
- Genetically predicted brain cortical structure mediates the causality between insulin resistance and cognitive impairment.Frontiers in endocrinology · 2024Article
- Genetic and non-genetic factors in prediction of early pubertal development in Chinese girls.Frontiers in endocrinology · 2024Article
- Authors' response to: A Mendelian randomization study of Alzheimer's disease and daytime napping.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Sleep and cardiovascular disease.Emerging topics in life sciences · 2023Review
- Selection of genetic instruments in Mendelian randomisation studies of sleep traits.Sleep medicine · 2023Review
- Causal associations between sleep traits and brain structure: a bidirectional Mendelian randomization study.Behavioral and brain functions : BBF · 2023Article
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Authors and funding
3 authors.
Funding
Abstract
objectivesDaytime napping has been associated with cognitive function and brain health in observational studies. However, it remains elusive whether these associations are causal. Using Mendelian randomization, we studied the relationship between habitual daytime napping and cognition and brain structure.
methodsData were from UK Biobank (maximum n = 378,932 and mean age = 57 years). Our exposure (daytime napping) was instrumented using 92 previously identified genome-wide, independent genetic variants (single-nucleotide polymorphisms, SNPs). Our outcomes were total brain volume, hippocampal volume, reaction time, and visual memory. Inverse-variance weighted was implemented, with sensitivity analyses (Mendelian randomization-Egger and Weighted Median Estimator) for horizontal pleiotropy. We tested different daytime napping instruments to ensure the robustness of our results.
resultsUsing Mendelian randomization, we found an association between habitual daytime napping and larger total brain volume (unstandardized ß = 15.80 cm
conclusionsOur findings suggest a modest causal association between habitual daytime napping and larger total brain volume. Future studies could focus on the associations between napping and other cognitive or brain outcomes and replication of these findings using other datasets and methods.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.