Evidence map›Paper›PMID 37344090›Full record

ArticleClinical nutrition ESPEN2023

Higher urea-to-albumin ratio is associated with mortality risk in critically ill COVID-19 patients.

Hellen Christina Neves Rodrigues, Mikaelly Luiz Silva, Milena Dos Santos Mantovani, Juliana Medeiros da Silva, Marielle Fernanda Panelli Domingues, Suzana Érico Tanni, Paula Schmidt Azevedo, Marcos Ferreira Minicucci, Marina Nogueira Berbel Buffarah, Amanda Gomes Pereira and 1 more

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Article in Clinical nutrition ESPEN, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hellen Christina Neves RodriguesFaculty of Nutrition, University Federal of Goiás-UFG, Goiânia, Brazil. Electronic address: hellenchrisnutri@hotmail.com.
Mikaelly Luiz SilvaClinical Hospital, University Federal of Goiás-UFG, Goiânia, Brazil.
Milena Dos Santos MantovaniClinical Hospital of Botucatu Medical School, São Paulo State University- UNESP, Botucatu, Brazil.
Juliana Medeiros da SilvaClinical Hospital of Botucatu Medical School, São Paulo State University- UNESP, Botucatu, Brazil.
Marielle Fernanda Panelli DominguesRegional Hospital Costa Magid Thomé, Três Lagoas, Brazil.
Suzana Érico TanniDepartment of Internal Medicine, Botucatu Medical School, São Paulo State University- UNESP, Botucatu, Brazil.
Paula Schmidt AzevedoDepartment of Internal Medicine, Botucatu Medical School, São Paulo State University- UNESP, Botucatu, Brazil.
Marcos Ferreira MinicucciDepartment of Internal Medicine, Botucatu Medical School, São Paulo State University- UNESP, Botucatu, Brazil.
Marina Nogueira Berbel BuffarahClinical Hospital of Botucatu Medical School, São Paulo State University- UNESP, Botucatu, Brazil.
Amanda Gomes PereiraFaculty of Medicine, University of São Paulo - USP, São Paulo, Brazil.
Nara Aline CostaFaculty of Nutrition, University Federal of Goiás-UFG, Goiânia, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to evaluate the ability of the urea-to-albumin ratio (UAR) to predict mortality in critically ill coronavirus disease 2019 (COVID-19) patients.

methodsThis retrospective study included adult patients admitted with COVID-19 at two intensive care units (ICUs) at the University Hospital. Serum urea and albumin concentrations at ICU admission were used to calculate the UAR. All patients were followed up during hospitalization, and the ICU mortality rate was recorded.

resultsTwo hundred and eleven patients were evaluated. The mean age was 57.8 ± 15.5 years, and 54% were male. Approximately 84.4% of patients were considered to be at nutritional risk by the NRS 2002, and the median UAR was 18.3 (10.5-34.8). The length of stay in the ICU was 10 (6-16) days, 38.4% of the patients required dialysis, and 64.9% died. Age, male sex, need of hemodialysis, lactate level, and inflammatory parameters were associated with higher mortality. Patients non-survivors had a higher UAR (23.7 [13.6-41.8] vs. 10.9 [8.5-16.8]; p < 0.001). The cutoff point with the best performance of UAR in the ROC curve for predicting mortality was ≥12.17 (AUC: 0.7201; CI 95%: 0.656-0.784). Additionally, the risk of mortality was 2.00-fold in the group of patients with UAR ≥12.17 (HR: 2.00 CI: 1.274-3.149; p = 0.003) and remained significant after adjusted analyzes (models 1 and 2).

conclusionOur data suggest that a UAR ≥12.17 increased the risk of mortality by 2.00-fold in critically ill COVID-19 patients.

Indexed as

COVID-19Serum Albumin, HumanUreaFemaleHumansIntensive Care UnitsMaleMiddle AgedPrognosisRetrospective StudiesSerum Albumin, HumanUreaCOVID-19Critical illnessMortalityUrea/albumin ratio

Identifiers

PMID37344090
PMCPMC10129333

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.