Evidence map›Paper›PMID 37343561›Full record

ArticleCell2023

Hindbrain modules differentially transform activity of single collicular neurons to coordinate movements.

Sebastian H Zahler, David E Taylor, Brennan S Wright, Joey Y Wong, Varvara A Shvareva, Yusol A Park, Evan H Feinberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Eye-head coordination during goal-directed orienting in mice.bioRxiv : the preprint server for biology · 2026
    Article
  3. Does Stimulation of Plantar Mechanoreceptors Alter Visual Spatial Localization?Journal of functional morphology and kinesiology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sebastian H ZahlerDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
David E TaylorDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Brennan S WrightDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Joey Y WongDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Varvara A ShvarevaDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Yusol A ParkDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Evan H FeinbergDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: evan.feinberg@ucsf.edu.

Funding

High-resolution neural circuit dissection with controllers locally affecting synaptic partners (CLASP)DP2MH119426 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FEINBERG, EVAN HARRIMAN · 2018 to 2018
$2.4M
Defining cell types that control action selection and executionR01NS109060 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FEINBERG, EVAN HARRIMAN · 2019 to 2023
$1.9M
NIMH NIH HHS DP2 MH119426NINDS NIH HHS R01 NS109060
6 · The paper itself

Abstract

Seemingly simple behaviors such as swatting a mosquito or glancing at a signpost involve the precise coordination of multiple body parts. Neural control of coordinated movements is widely thought to entail transforming a desired overall displacement into displacements for each body part. Here we reveal a different logic implemented in the mouse gaze system. Stimulating superior colliculus (SC) elicits head movements with stereotyped displacements but eye movements with stereotyped endpoints. This is achieved by individual SC neurons whose branched axons innervate modules in medulla and pons that drive head movements with stereotyped displacements and eye movements with stereotyped endpoints, respectively. Thus, single neurons specify a mixture of endpoints and displacements for different body parts, not overall displacement, with displacements for different body parts computed at distinct anatomical stages. Our study establishes an approach for unraveling motor hierarchies and identifies a logic for coordinating movements and the resulting pose.

Indexed as

Fixation, OcularSaccadesAnimalsEye MovementsHead MovementsMiceNeuronsRhombencephalonSuperior Colliculiethologygazehindbrainmotor controlmovement coordinationorientingsaccadessignal multiplexingsuperior colliculussystems neuroscienceupper motor neurons

Identifiers

PMID37343561
PMCPMC10424787

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.