ArticleScience translational medicine2023
An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor.
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Article in Science translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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0cells of the map it votes in
47citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
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Who cites it
47 citing papers in PubMed, 54 citations in OpenAlex.
- Sustained Activation of CaMKII Promotes Skeletal Muscle Contractile Dysfunction in Aging.Aging cell · 2026Article
- An RYR2-interacting fragment of MYBPC3 mitigates arrhythmia in human iPSC-CM and mouse models of CPVT.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Exploring the role of CaMKII in exercise-induced cardioprotection.Human cell · 2026Review
- The Immune System as a Proarrhythmic Mediator: A Novel Paradigm for the Development of New Antiarrhythmic Therapy.The Canadian journal of cardiology · 2026Review
- Maternal hyperglycemia-induced O-GlcNAcylation of CaMKIIδ promotes mtDNA release and cardiac remodeling in offspring.Nature communications · 2026Article
- The clinical pathophysiology of atrial fibrillation: outstanding questions from bedside to bench and back.Physiological reviews · 2026Review
- Atrial Fibrillation Beyond the Atrium.JACC. Basic to translational science · 2026Article
- Prioritizing Discovery and Advancements in Arrhythmia Therapies: NIH/NHLBI Workshop.JACC. Clinical electrophysiology · 2026Review
- Atrial Fibrillation Increases Proarrhythmic Mechanisms in the Ventricle.JACC. Basic to translational science · 2026Article
- Dynamic visualization of physiological CaMKII activity using sensitive FRET biosensors.bioRxiv : the preprint server for biology · 2026Article
- CAMK2D causes heart failure in mice with RBM20 cardiomyopathy.Nature cardiovascular research · 2026Article
- Wntless degradation mediated by CaMKII inhibition drives endoplasmic reticulum stress and apoptosis.Cell reports · 2026Article
- Atrial fibrillation associated with tyrosine kinase inhibitors: A case-control study of real-world pharmacovigilance data.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Danhong Injection targets CaMKII through Dihydrotanshinone I to alleviate cardiomyocyte death and inflammation in viral myocarditis.Science China. Life sciences · 2026Article
- Cyclic AMP-dependent regulation of ryanodine receptors in healthy and diseased hearts.Journal of molecular and cellular cardiology · 2026Review
- Gastrointestinal toxicity associated with cyclin-dependent kinase 4/6 inhibitors in breast cancer patients: insights from a real-world pharmacovigilance analysis.Frontiers in medicine · 2026Article
- 3D Cardiac Constructs in Drug Discovery: Current Advances and Future Challenges.Research (Washington, D.C.) · 2026Review
- Longitudinal prospective analysis of organ stiffness and cardiac function in patients with myelofibrosis treated with ruxolitinib type of study: Prospective single-center cohort study.Therapeutic advances in hematology · 2026Article
- Role of ruxolitinib in preventing cardiac arrhythmias: A pooled analysis of clinical studies in hematology.International journal of cardiology. Heart & vasculature · 2025Article
- High-throughput screens identify genotype-specific therapeutics for channelopathies.JCI insight · 2025Article
Corrections and comments
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Authors and funding
22 authors at 4 institutions in 2 countries.
Oscar E Reyes GaidoDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-2044-8489
Nikoleta PavlakiDepartment of Cardiology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-5484-192X
Jonathan M GrangerDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-0848-9547
Olurotimi O MesubiDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-4700-356X
Bian LiuSolomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-8806-820X
Brian L LinDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-0800-7103
Alan LongDepartment of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
David WalkerDepartment of Cardiology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-4986-151X
Joshua MayourianDepartment of Cardiology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Kate L ScholeDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Chantelle E TerrillionDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Lubika J NkashamaDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-4898-8594
Mohit M HulsurkarCardiovascular Research Institute and Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-0595-6661
Lauren E DornCardiovascular Research Institute and Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-2726-9600
Kimberly M FerreroDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-9711-7683
Richard L HuganirSolomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-9783-5183
Frank U MüllerInstitute of Pharmacology and Toxicology, University of Münster, Münster 48149, Germany.ORCID 0000-0002-4896-2511
Xander H T WehrensCardiovascular Research Institute and Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.
Jun O LiuDepartment of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Elizabeth D LuczakDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-7753-089X
Vassilios J BezzeridesDepartment of Cardiology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-0825-6580
Mark E AndersonDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-6145-5234
Johns Hopkins University · USBoston Children's Hospital · USBaylor College of Medicine · USUniversity of Münster · DE
Funding
Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4MRyanodine receptor regulation in post-operative atrial fibrillationR01HL089598 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2007 to 2022
$6.5MCaMKII signaling in physiology, heart failure and arrhythmiasR35HL140034 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ANDERSON, MARK E · 2018 to 2022
$5.2MImmersive Training in GlycosciencesK12HL141952 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HASCALL, VINCENT CHARLES, SCHNAAR, RONALD L · 2018 to 2022
$4.8MDevelopment of kinase biosensors for multiplex neuronal imaging of signaling pathways in behaving miceRF1MH126707 · NIMH · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L, ZHANG, JIN · 2022 to 2022
$2.4MJunctophilin-2 cleavage in ischemic heart diseaseR01HL153350 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2021 to 2024
$2.3MRole of Nucleoside-Diphosphate Kinase Signaling in Atrial FibrillationR01HL160992 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Xander H.T. Wehrens · 2023 to 2026
$2.1MMechanisms underlying atrial fibrillation associated with chronic kidney diseaseR01HL147108 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LI, NA, WEHRENS, XANDER H.T. · 2019 to 2022
$2.0MTissue chips for precision treatment of catecholaminergic polymorphic ventricular tachycardiaUG3TR003279 · NCATS · BOSTON CHILDREN'S HOSPITAL · PI PARKER, KEVIN KIT, PU, WILLIAM TSWENCHING · 2020 to 2021
$1.8MNovel molecular therapies for CPVTK08HL140197 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI BEZZERIDES, VASSILIOS JAMES · 2018 to 2022
$851kTRPC6 inhibition therapy to rescue cardiac muscle dysfunction in muscular dystrophyK99HL155840 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI LIN, BRIAN LEEI · 2022 to 2023
$261kNCATS NIH HHS UG3 TR003279NHLBI NIH HHS K08 HL140197NHLBI NIH HHS K12 HL141952NHLBI NIH HHS K99 HL155840NHLBI NIH HHS R01 HL089598NHLBI NIH HHS R01 HL147108NHLBI NIH HHS R01 HL153350NHLBI NIH HHS R01 HL160992NHLBI NIH HHS R35 HL140034NIGMS NIH HHS T32 GM136577NIMH NIH HHS RF1 MH126707
Abstract
Ca
Indexed as
Calcium-Calmodulin-Dependent Protein Kinase Type 2Heart DiseasesAnimalsArrhythmias, CardiacCalciumChildHumansMiceMyocytes, CardiacNitrilesPyrazolesPyrimidinesCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2NitrilesPyrazolesPyrimidinesruxolitinib
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.