Evidence map›Paper›PMID 37342846›Full record

ArticleWorld journal of gastrointestinal surgery2023

Rikkunshito increases appetite by enhancing gastrointestinal and incretin hormone levels in patients who underwent pylorus-preserving pancreaticoduodenectomy: A retrospective study.

Hiroshi Kono, Naohiro Hosomura, Hidetake Amemiya, Katsutoshi Shoda, Shinji Furuya, Hidenori Akaike, Yoshihiko Kawaguchi, Hiromichi Kawaida, Daisuke Ichikawa

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastrointestinal surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Hiroshi KonoFirst Department of Surgery, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan. hkouno@yamanashi.ac.jp.
Naohiro HosomuraFirst Department of Surgery, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan.
Hidetake AmemiyaFirst Department of Surgery, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan.
Katsutoshi ShodaFirst Department of Surgery, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan.
Shinji FuruyaFirst Department of Surgery, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan.
Hidenori AkaikeFirst Department of Surgery, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan.
Yoshihiko KawaguchiFirst Department of Surgery, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan.
Hiromichi KawaidaFirst Department of Surgery, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan.
Daisuke IchikawaFirst Department of Surgery, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan.
University of Yamanashi Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRikkunshito (TJ-43) relieves gastrointestinal disturbance by increases in the levels of acylated ghrelin.

aimTo investigate the effects of TJ-43 in patients undergoing pancreatic surgery.

methodsForty-one patients undergoing pylorus-preserving pancreaticoduodenectomy (PpPD) were divided into two groups; patients took daily doses of TJ-43 after surgery or after postoperative day (POD) 21. The plasma levels of acylated and desacylated ghrelin, cholecystokinin (CCK), peptide YY (PYY), gastric inhibitory peptide (GIP), and active glucagon-like peptide (GLP)-1 were evaluated. Oral calorie intake was assessed at POD 21 in both groups. The primary endpoint of this study was the total food intake after PpPD.

resultsThe levels of acylated ghrelin were significantly greater in patients treated with TJ-43 than those in patients without TJ-43 administration at POD 21, and oral intake was significantly increased in patients treated with TJ-43. The CCK and PYY levels were significantly greater in patients treated with TJ-43 than those in patients without TJ-43 treatment. Furthermore, the GIP and active GLP-1 levels increased and values at POD 21 were significantly greater in patients treated with TJ-43 than those in patients without TJ-43 administration. Insulin secretion tended to increase in patients treated with TJ-43.

conclusionTJ-43 may have advantages for oral food intake in patients in the early phase after pancreatic surgery. Further investigation is needed to clarify the effects of TJ-43 on incretin hormones.

Indexed as

Gastrointestinal hormoneGhrelinIncretinJapanese traditional herbal medicinePancreatic surgery

Identifiers

PMID37342846
PMCPMC10277958
OpenAlexW4378192519

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.