Evidence map›Paper›PMID 37342758›Full record

ArticleEuropean journal of operational research2023

The hammer and the jab: Are COVID-19 lockdowns and vaccinations complements or substitutes?

J P Caulkins, D Grass, G Feichtinger, R F Hartl, P M Kort, M Kuhn, A Prskawetz, M Sanchez-Romero, A Seidl, S Wrzaczek

Abstract read
In one paragraph

Article in European journal of operational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

J P CaulkinsHeinz College, Carnegie Mellon University, Pittsburgh, USA.
D GrassInternational Institute for Applied Systems Analysis (IIASA), Schlossplatz 1, Laxenburg 2361, Austria.
G FeichtingerDepartment for Operations Research and Control Systems, Institute of Statistics and Mathematical Methods in Economics, Vienna University of Technology, Vienna, Austria.
R F HartlDepartment of Business Decisions and Analytics, University of Vienna, Vienna, Austria.
P M KortTilburg School of Economics and Management, Tilburg University, Tilburg, Netherlands.
M KuhnInternational Institute for Applied Systems Analysis (IIASA), Schlossplatz 1, Laxenburg 2361, Austria.
A PrskawetzInternational Institute for Applied Systems Analysis (IIASA), Schlossplatz 1, Laxenburg 2361, Austria.
M Sanchez-RomeroInternational Institute for Applied Systems Analysis (IIASA), Schlossplatz 1, Laxenburg 2361, Austria.
A SeidlDepartment of Business Decisions and Analytics, University of Vienna, Vienna, Austria.
S WrzaczekInternational Institute for Applied Systems Analysis (IIASA), Schlossplatz 1, Laxenburg 2361, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic has devastated lives and economies around the world. Initially a primary response was locking down parts of the economy to reduce social interactions and, hence, the virus' spread. After vaccines have been developed and produced in sufficient quantity, they can largely replace broad lock downs. This paper explores how lockdown policies should be varied during the year or so gap between when a vaccine is approved and when all who wish have been vaccinated. Are vaccines and lockdowns substitutes during that crucial time, in the sense that lockdowns should be reduced as vaccination rates rise? Or might they be complementary with the prospect of imminent vaccination increasing the value of stricter lockdowns, since hospitalization and death averted then may be permanently prevented, not just delayed? We investigate this question with a simple dynamic optimization model that captures both epidemiological and economic considerations. In this model, increasing the rate of vaccine deployment may increase or reduce the optimal total lockdown intensity and duration, depending on the values of other model parameters. That vaccines and lockdowns can act as either substitutes or complements even in a relatively simple model casts doubt on whether in more complicated models or the real world one should expect them to always be just one or the other. Within our model, for parameter values reflecting conditions in developed countries, the typical finding is to ease lockdown intensity gradually after substantial shares of the population have been vaccinated, but other strategies can be optimal for other parameter values. Reserving vaccines for those who have not yet been infected barely outperforms simpler strategies that ignore prior infection status. For certain parameter combinations, there are instances in which two quite different policies can perform equally well, and sometimes very small increases in vaccine capacity can tip the optimal solution to one that involves much longer and more intense lockdowns.

Indexed as

COVID-19Dynamic optimizationOR In governmentSIR ModelsVaccinations

Identifiers

PMID37342758
PMCPMC10131897

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.