ArticleBiomedical optics express2023
Characteristics of Henle's fiber layer in healthy and glaucoma eyes assessed by polarization-sensitive optical coherence tomography.
Article in Biomedical optics express, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Henle Fibers Are Organized in Bundles Consistent Between Individuals and Conserved in Primates.Investigative ophthalmology & visual science · 2026Article
- Multimodal Imaging of Dual BEST1/EFEMP1-Associated Hereditary Macular Disease.Journal of clinical medicine · 2026Article
- High-speed, wide-field, fiber-based PS-OCT system with real-time surface Stokes feedback for circular input polarization.Biomedical optics express · 2026Article
- Assessing the Relationship between Foveal Cone Density, Outer Nuclear Layer Thickness and Foveal Morphology.Ophthalmology science · 2026Article
- A novel computational model for human macular pigment optical density and its relationship to foveal structure.Scientific reports · 2025Article
- Article
- Three-dimensional C-scan-based generation adversarial network with synthetic input to improve optical coherence tomography angiography.Journal of biomedical optics · 2025Article
- Normalization of Retinal Birefringence Scanning Signals.Sensors (Basel, Switzerland) · 2024Article
- Digital calibration method to enable depth-resolved all-fiber polarization sensitive optical coherence tomography with an arbitrary input polarization state.Biomedical optics express · 2024Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Using conventional optical coherence tomography (OCT), it is difficult to image Henle fibers (HF) due to their low backscattering potential. However, fibrous structures exhibit form birefringence, which can be exploited to visualize the presence of HF by polarization-sensitive (PS) OCT. We found a slight asymmetry in the retardation pattern of HF in the fovea region that can be associated with the asymmetric decrease of cone density with eccentricity from the fovea. We introduce a new measure based on a PS-OCT assessment of optic axis orientation to estimate the presence of HF at various eccentricities from the fovea in a large cohort of 150 healthy subjects. By comparing a healthy age-matched sub-group (N = 87) to a cohort of 64 early-stage glaucoma patients, we found no significant difference in HF extension but a slightly decreased retardation at about 2° to 7.5° eccentricity from the fovea in the glaucoma patients. This potentially indicates that glaucoma affects this neuronal tissue at an early state.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.