Physics-guided neural network for tissue optical properties estimation.

Finding the optical properties of tissue is essential for various biomedical diagnostic/therapeutic applications such as monitoring of blood oxygenation, tissue metabolism, skin imaging, photodynamic therapy, low-level laser therapy, and photo-thermal therapy. Hence, the research for more accurate and versatile optical properties estimation techniques has always been a primary interest of researchers, especially in the field of bioimaging and bio-optics. In the past, most of the prediction methods were based on physics-based models such as the pronounced diffusion approximation method. In more recent years, with the advancement and growing popularity of machine learning techniques, most of the prediction methods are data-driven. While both methods have been proven to be useful, each of them suffers from several shortcomings that could be complemented by their counterparts. Thus, there is a need to bring the two domains together to obtain superior prediction accuracy and generalizability. In this work, we proposed a physics-guided neural network (PGNN) for tissue optical properties regression which integrates physics prior and constraint into the artificial neural network (ANN) model. With this method, we have demonstrated superior generalizability of PGNN compared to its pure ANN counterpart. The prediction accuracy and generalizability of the network were evaluated on single-layered tissue samples simulated with Monte Carlo simulation. Two different test datasets, the in-domain test dataset and out-domain dataset were used to evaluate in-domain generalizability and out-domain generalizability, respectively. The physics-guided neural network (PGNN) showed superior generalizability for both in-domain and out-domain prediction compared to pure ANN.