ArticleBiomedical optics express2023
Spatial frequency domain imaging for the assessment of scleroderma skin involvement.
Article in Biomedical optics express, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 5 citations in OpenAlex.
- Two-step regression analysis approach to assess burn wound severity using spatial frequency domain imaging.Journal of biomedical optics · 2026Article
- Structured light imaging mesoscopy: detection of embedded morphological changes in superficial tissues.Journal of biomedical optics · 2025Article
- Laser speckle size and contrast investigation of volumetric scattering from controlled turbid phantoms and mouse skin tissues.iScience · 2025Article
- Deep-learning-enabled spatial frequency domain imaging of the spatiotemporal dynamics of skin physiology.Journal of biomedical optics · 2025Article
- Structured light imaging mesoscopy: application to skin changes in scleroderma.Biophotonics discovery · 2025Article
- Using spatial frequency domain imaging to monitor a skin biopsy wound: a pilot study.Biomedical optics express · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemic sclerosis (SSc) is an autoimmune disease characterized by the widespread deposition of excess collagen in the skin and internal organs, as well as vascular dysfunction. The current standard of care technique used to quantify the extent of skin fibrosis in SSc patients is the modified Rodnan skin score (mRSS), which is an assessment of skin thickness based on clinical palpation. Despite being considered the gold standard, mRSS testing requires a trained physician and suffers from high inter-observer variability. In this study, we evaluated the use of spatial frequency domain imaging (SFDI) as a more quantitative and reliable method for assessing skin fibrosis in SSc patients. SFDI is a wide-field and non-contact imaging technique that utilizes spatially modulated light to generate a map of optical properties in biological tissue. The SFDI data were collected at six measurement sites (left and right forearms, hands, and fingers) of eight control subjects and ten SSc patients. mRSS were assessed by a physician, and skin biopsies were collected from subject's forearms and used to assess for markers of skin fibrosis. Our results indicate that SFDI is sensitive to skin changes even at an early stage, as we found a significant difference in the measured optical scattering (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.