Evidence map›Paper›PMID 37342698›Full record

ArticleBiomedical optics express2023

Temporal focusing multiphoton microscopy with cross-modality multi-stage 3D U-Net for fast and clear bioimaging.

Yvonne Yuling Hu, Chia-Wei Hsu, Yu-Hao Tseng, Chun-Yu Lin, Hsueh-Cheng Chiang, Ann-Shyn Chiang, Shin-Tsu Chang, Shean-Jen Chen

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Yvonne Yuling HuDepartment of Photonics, National Cheng Kung University, Tainan 701, Taiwan.ORCID https://orcid.org/0000-0002-5297-913X
Chia-Wei HsuCollege of Photonics, National Yang Ming Chiao Tung University, Tainan 711, Taiwan.
Yu-Hao TsengCollege of Photonics, National Yang Ming Chiao Tung University, Tainan 711, Taiwan.
Chun-Yu LinCollege of Photonics, National Yang Ming Chiao Tung University, Tainan 711, Taiwan.
Hsueh-Cheng ChiangDepartment of Pharmacology, National Cheng Kung University, Tainan 701, Taiwan.
Ann-Shyn ChiangBrain Research Center, National Tsing Hua University, Hsinchu 300, Taiwan.
Shin-Tsu ChangDepartment of Physical Medicine and Rehabilitation, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan.
Shean-Jen ChenDepartment of Photonics, National Cheng Kung University, Tainan 701, Taiwan.
National Yang Ming Chiao Tung University · TWNational Cheng Kung University · TWKaohsiung Veterans General Hospital · TWNational Tsing Hua University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Temporal focusing multiphoton excitation microscopy (TFMPEM) enables fast widefield biotissue imaging with optical sectioning. However, under widefield illumination, the imaging performance is severely degraded by scattering effects, which induce signal crosstalk and a low signal-to-noise ratio in the detection process, particularly when imaging deep layers. Accordingly, the present study proposes a cross-modality learning-based neural network method for performing image registration and restoration. In the proposed method, the point-scanning multiphoton excitation microscopy images are registered to the TFMPEM images by an unsupervised U-Net model based on a global linear affine transformation process and local VoxelMorph registration network. A multi-stage 3D U-Net model with a cross-stage feature fusion mechanism and self-supervised attention module is then used to infer

Identifiers

PMID37342698
PMCPMC10278625
OpenAlexW4367181481

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.