Evidence map›Paper›PMID 37342684›Full record

ArticleBiomedical optics express2023

DIRECT, a low-cost system for high-speed, low-noise imaging of fluorescent bio-samples.

Isabell Whiteley, Chenchen Song, Glenn A Howe, Thomas Knöpfel, Christopher J Rowlands

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Light-field deep learning enables high-throughput, scattering-mitigated calcium imaging.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Color-neutral and reversible tissue transparency enables longitudinal deep-tissue imaging in live mice.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Isabell WhiteleyDepartment of Bioengineering, Imperial College London, London, UK.ORCID https://orcid.org/0000-0003-2460-678X
Chenchen SongDepartment of Brain Sciences, Imperial College London, London, UK.
Glenn A HoweDepartment of Bioengineering, Imperial College London, London, UK.
Thomas KnöpfelCentre for Neurotechnology, Imperial College London, London, UK.ORCID https://orcid.org/0000-0002-5718-0765
Christopher J RowlandsDepartment of Bioengineering, Imperial College London, London, UK.ORCID https://orcid.org/0000-0002-8261-2371
Imperial College London · GBLondon Centre for Nanotechnology · GBHong Kong Baptist University · HK

Funding

Near Infrared Genetically Encoded Voltage Indicators (NIR-GEVIs) for All-Optical Electrophysiology (AOE)U01NS099573 · NINDS · IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE · PI ANTIC, SRDJAN D, KNOPFEL, THOMAS · 2016 to 2018
$2.9M
Sparse, Strong and Large Area Targeting of Genetically Encoded IndicatorsU01MH109091 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI ANTIC, SRDJAN D, KNOPFEL, THOMAS · 2015 to 2017
$1.6M
NIMH NIH HHS U01 MH109091NINDS NIH HHS U01 NS099573Wellcome Trust
6 · The paper itself

Abstract

A targeted imaging system has been developed for applications requiring recording from stationary samples at high spatiotemporal resolutions. It works by illuminating regions of interest in rapid sequence, and recording the signal from the whole field of view onto a single photodetector. It can be implemented at low cost on an existing microscope without compromising existing functionality. The system is characterized in terms of speed, spatial resolution, and tissue penetration depth, before being used to record individual action potentials from ASAP-3 expressing neurons in an

Identifiers

PMID37342684
PMCPMC10278627
OpenAlexW4367320233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.