Evidence map›Paper›PMID 37342515›Full record

ReviewApplied biosafety : journal of the American Biological Safety Association2023

The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory-SARS-CoV-2.

Stuart D Blacksell, Sandhya Dhawan, Marina Kusumoto, Kim Khanh Le, Kathrin Summermatter, Joseph O'Keefe, Joseph Kozlovac, Salama Suhail Almuhairi, Indrawati Sendow, Christina M Scheel and 5 more

Open access · hybridAbstract readReview
In one paragraph

Review in Applied biosafety : journal of the American Biological Safety Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Findings and Recommendations of the RAV3N Applied Biorisk and Biosafety Gap Assessment Workshop.Applied biosafety : journal of the American Biological Safety Association · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 12 institutions in 11 countries.

Stuart D BlacksellMahidol-Oxford Tropical Research Medicine Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Sandhya DhawanMahidol-Oxford Tropical Research Medicine Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Marina KusumotoMahidol-Oxford Tropical Research Medicine Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Kim Khanh LeMahidol-Oxford Tropical Research Medicine Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Kathrin SummermatterInstitute for Infectious Diseases, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0001-5519-5966
Joseph O'KeefeMinistry for Primary Industries, Wellington, New Zealand.
Joseph KozlovacU.S. Department of Agriculture, Agricultural Research Service, Beltsville, Maryland, USA.
Salama Suhail AlmuhairiAbu Dhabi Agriculture and Food Safety Authority, Abu Dhabi, United Arab Emirates.
Indrawati SendowResearch Center for Veterinary Science, National Research and Innovation Agency, Indonesia.
Christina M ScheelWHO Collaborating Center for Biosafety and Biosecurity, Office of the Associate Director for Laboratory Science, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Anthony AhumibeNigeria Centre for Disease Control and Prevention, Abuja, Nigeria.ORCID https://orcid.org/0000-0002-4651-4424
Zibusiso M MasukuNational Institute for Communicable Diseases of the National Health Laboratory Services, Sandringham, South Africa.
Kazunobu KojimaDepartment of Epidemic and Pandemic Preparedness and Prevention, World Health Organization, Geneva, Switzerland.
David R HarperThe Royal Institute of International Affairs, London, United Kingdom.
Keith HamiltonWorld Organisation for Animal Health (OIE), Paris, France.
Mahidol University · THAbu Dhabi Health Services · AEAgricultural Research Service · USCenters for Disease Control and Prevention · UGChatham House · GBMinistry for Primary Industries · NZNational Health Laboratory Service · ZANational Research and Innovation Agency · IDNigeria Centre for Disease Control · NGOrganisation Mondiale de la Santé Animale · FRUniversity of Bern · CHWorld Health Organization · CH

Funding

World Health Organization 001
6 · The paper itself

Abstract

Introduction: The SARS-CoV-2 virus emerged as a novel virus and is the causative agent of the COVID-19 pandemic. It spreads readily human-to-human through droplets and aerosols. The Biosafety Research Roadmap aims to support the application of laboratory biological risk management by providing an evidence base for biosafety measures. This involves assessing the current biorisk management evidence base, identifying research and capability gaps, and providing recommendations on how an evidence-based approach can support biosafety and biosecurity, including in low-resource settings. Methods: A literature search was conducted to identify potential gaps in biosafety and focused on five main sections, including the route of inoculation/modes of transmission, infectious dose, laboratory-acquired infections, containment releases, and disinfection and decontamination strategies. Results: There are many knowledge gaps related to biosafety and biosecurity due to the SARS-CoV-2 virus's novelty, including infectious dose between variants, personal protective equipment for personnel handling samples while performing rapid diagnostic tests, and laboratory-acquired infections. Detecting vulnerabilities in the biorisk assessment for each agent is essential to contribute to the improvement and development of laboratory biosafety in local and national systems.

Indexed as

biorisk managementbiosafety evidencebiosafety knowledge gappathogen characteristicsSARS-CoV-2

Identifiers

PMID37342515
PMCPMC10278019
OpenAlexW4376618862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.