Evidence map›Paper›PMID 37342054›Full record

ArticleTranslational vision science & technology2023

Fundus Tessellated Density Assessed by Deep Learning in Primary School Children.

Dan Huang, Rui Li, Yingxiao Qian, Saiguang Ling, Zhou Dong, Xin Ke, Qi Yan, Haohai Tong, Zijin Wang, Tengfei Long and 2 more

Open access · goldAbstract read
In one paragraph

Article in Translational vision science & technology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Dan HuangDepartment of Ophthalmology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, Jiangsu, China.
Rui LiDepartment of Ophthalmology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, Jiangsu, China.
Yingxiao QianDepartment of Ophthalmology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, Jiangsu, China.
Saiguang LingEVision Technology (Beijing) Co. LTD, Beijing, China.
Zhou DongEVision Technology (Beijing) Co. LTD, Beijing, China.
Xin KeEVision Technology (Beijing) Co. LTD, Beijing, China.
Qi YanDepartment of Ophthalmology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, Jiangsu, China.
Haohai TongThe Second Affiliated Hospital, Zhejiang University School of Medicine, Eye Center, Hangzhou, Zhejiang, China.
Zijin WangDepartment of Ophthalmology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, Jiangsu, China.
Tengfei LongAerospace Information Research Institute, Chinese Academy of Sciences (CAS), Beijing, China.
Hu LiuDepartment of Ophthalmology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, Jiangsu, China.
Hui ZhuDepartment of Ophthalmology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, Jiangsu, China.
Nanjing Medical University · CNInferVision (China) · CNChinese Academy of Sciences · CNSecond Affiliated Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To explore associations of fundus tessellated density (FTD) and compare characteristics of different fundus tessellation (FT) distribution patterns, based on artificial intelligence technology using deep learning. Methods: Comprehensive ocular examinations were conducted in 577 children aged 7 years old from a population-based cross-sectional study, including biometric measurement, refraction, optical coherence tomography angiography, and 45° nonmydriatic fundus photography. FTD was defined as the average exposed choroid area per unit area of the fundus, and obtained by artificial intelligence technology. The distribution of FT was classified into the macular pattern and the peripapillary pattern according to FTD. Results: The mean FTD was 0.024 ± 0.026 in whole fundus. Multivariate regression analysis showed that greater FTD was significantly correlated with thinner subfoveal choroidal thickness, larger parapapillary atrophy, greater vessel density inside the optic disc, larger vertical diameter of optic disc, thinner retinal nerve fiber layer, and longer distance from optic disc center to macular fovea (all P < 0.05). The peripapillary distributed group had larger parapapillary atrophy (0.052 ± 0.119 vs 0.031 ± 0.072), greater FTD (0.029 ± 0.028 vs 0.015 ± 0.018), thinner subfoveal choroidal thickness (297.66 ± 60.61 vs 315.33 ± 66.46), and thinner retinal thickness (285.55 ± 10.89 vs 288.03 ± 10.31) than the macular distributed group (all P < 0.05). Conclusions: FTD can be applied as a quantitative biomarker to estimate subfoveal choroidal thickness in children. The role of blood flow inside optic disc in FT progression needs further investigation. The distribution of FT and the peripapillary pattern correlated more with myopia-related fundus changes than the macular pattern. Translational Relevance: Artificial intelligence can evaluate FT quantitatively in children, and has potential value for assisting in myopia prevention and control.

Indexed as

Deep LearningMyopiaArtificial IntelligenceAtrophyChildCross-Sectional StudiesHumansSchools

Identifiers

PMID37342054
PMCPMC10289270
OpenAlexW4381469976

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.