ArticleBrain informatics2023
Enhancing biofeedback-driven self-guided virtual reality exposure therapy through arousal detection from multimodal data using machine learning.
Article in Brain informatics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Artificial intelligence (AI) for virtual reality exposure therapy (VRET): A systematic review.Translational psychiatry · 2026Pooled it
- Effectiveness of biofeedback on blood pressure in patients with hypertension: systematic review and meta-analysis.Journal of human hypertension · 2024Pooled it
- Effectiveness of immersive VR therapy in reducing stress-associated symptoms in Ukraine.European journal of psychotraumatology · 2025Trial
- Artificial Intelligence-Integrated Virtual Reality in Mental Health Care: A Scoping Review of Evidence, Clinical Applications, and Future Directions.Journal of clinical medicine · 2026Review
- Can reinforcement learning effectively prevent depression relapse?World journal of psychiatry · 2025Review
- SAFEvR MentalVeRse.app: Development of a Free Immersive Virtual Reality Exposure Therapy for Acrophobia and Claustrophobia.Brain sciences · 2024Article
- Virtual Reality Utilized for Safety Skills Training for Autistic Individuals: A Review.Behavioral sciences (Basel, Switzerland) · 2024Review
- Exploring protocol development: Implementing systematic contextual memory to enhance real-time fMRI neurofeedback.Journal of electrical bioimpedance · 2024Article
- Detection of arousal and valence from facial expressions and physiological responses evoked by different types of stressors.Frontiers in neuroergonomics · 2024Article
- Machine learning prediction of anxiety symptoms in social anxiety disorder: utilizing multimodal data from virtual reality sessions.Frontiers in psychiatry · 2024Article
- Explainable feature selection and deep learning based emotion recognition in virtual reality using eye tracker and physiological data.Frontiers in medicine · 2024Article
- Enhancing biofeedback-driven self-guided virtual reality exposure therapy through arousal detection from multimodal data using machine learning.Brain informatics · 2023Article
Corrections and comments
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Authors and funding
17 authors.
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Abstract
Virtual reality exposure therapy (VRET) is a novel intervention technique that allows individuals to experience anxiety-evoking stimuli in a safe environment, recognise specific triggers and gradually increase their exposure to perceived threats. Public-speaking anxiety (PSA) is a prevalent form of social anxiety, characterised by stressful arousal and anxiety generated when presenting to an audience. In self-guided VRET, participants can gradually increase their tolerance to exposure and reduce anxiety-induced arousal and PSA over time. However, creating such a VR environment and determining physiological indices of anxiety-induced arousal or distress is an open challenge. Environment modelling, character creation and animation, psychological state determination and the use of machine learning (ML) models for anxiety or stress detection are equally important, and multi-disciplinary expertise is required. In this work, we have explored a series of ML models with publicly available data sets (using electroencephalogram and heart rate variability) to predict arousal states. If we can detect anxiety-induced arousal, we can trigger calming activities to allow individuals to cope with and overcome distress. Here, we discuss the means of effective selection of ML models and parameters in arousal detection. We propose a pipeline to overcome the model selection problem with different parameter settings in the context of virtual reality exposure therapy. This pipeline can be extended to other domains of interest where arousal detection is crucial. Finally, we have implemented a biofeedback framework for VRET where we successfully provided feedback as a form of heart rate and brain laterality index from our acquired multimodal data for psychological intervention to overcome anxiety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.