Evidence map›Paper›PMID 37341704›Full record

ArticleBiomacromolecules2023

Nanocellulose Reinforced Hyaluronan-Based Bioinks.

Andrea Träger, Sajjad Naeimipour, Michael Jury, Robert Selegård, Daniel Aili

Abstract read
In one paragraph

Article in Biomacromolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Effective and new technologies in kidney tissue engineering.Frontiers in bioengineering and biotechnology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrea TrägerLaboratory of Molecular Materials, Division of Biophysics and Bioengineering, Department of Physics, Chemistry and Biology, Linköping University, 581 83 Linköping, Sweden.ORCID 0000-0001-6180-8917
Sajjad NaeimipourLaboratory of Molecular Materials, Division of Biophysics and Bioengineering, Department of Physics, Chemistry and Biology, Linköping University, 581 83 Linköping, Sweden.
Michael JuryLaboratory of Molecular Materials, Division of Biophysics and Bioengineering, Department of Physics, Chemistry and Biology, Linköping University, 581 83 Linköping, Sweden.
Robert SelegårdLaboratory of Molecular Materials, Division of Biophysics and Bioengineering, Department of Physics, Chemistry and Biology, Linköping University, 581 83 Linköping, Sweden.ORCID 0000-0002-1781-1489
Daniel AiliLaboratory of Molecular Materials, Division of Biophysics and Bioengineering, Department of Physics, Chemistry and Biology, Linköping University, 581 83 Linköping, Sweden.ORCID 0000-0002-7001-9415

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bioprinting of hydrogel-based bioinks can allow for the fabrication of elaborate, cell-laden 3D structures. In addition to providing an adequate extracellular matrix mimetic environment and high cell viability, the hydrogels must offer facile extrusion through the printing nozzle and retain the shape of the printed structure. We demonstrate a strategy to incorporate cellulose oxalate nanofibrils in hyaluronan-based hydrogels to generate shear thinning bioinks that allowed for printing of free-standing multilayer structures, covalently cross-linked after bioprinting, yielding long-term stability. The storage modulus of the hydrogels was tunable between 0.5 and 1.5 kPa. The nanocellulose containing hydrogels showed good biocompatibility, with viability of primary human dermal fibroblasts above 80% at day 7 after seeding. The cells were also shown to tolerate the printing process well, with viability above 80% 24 h after printing. We anticipate that this hydrogel system can find broad use as a bioink to produce complex geometries that can support cell growth.

Indexed as

BioprintingHyaluronic AcidCell SurvivalHumansHydrogelsPrinting, Three-DimensionalRheologyTissue EngineeringTissue ScaffoldsHyaluronic AcidHydrogels

Identifiers

PMID37341704
PMCPMC10336840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.