Evidence map›Paper›PMID 37341610›Full record

ArticleMicrobiology spectrum2023

Mouse Liver-Expressed Shiftless Is an Evolutionarily Conserved Antiviral Effector Restricting Human and Murine Hepaciviruses.

Yudi Zhang, Volker Kinast, Julie Sheldon, Nicola Frericks, Daniel Todt, Matthias Zimmer, Neva Caliskan, Richard J P Brown, Eike Steinmann, Thomas Pietschmann

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Yudi Zhang *Institute for Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany.
Volker Kinast *Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.
Julie SheldonInstitute for Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany.
Nicola FrericksInstitute for Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany.
Daniel TodtDepartment for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.
Matthias ZimmerHelmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Zentrum für Infektionsforschung (Helmholtz Centre for Infection Research), Würzburg, Germany.
Neva CaliskanHelmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Zentrum für Infektionsforschung (Helmholtz Centre for Infection Research), Würzburg, Germany.
Richard J P BrownDepartment for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.ORCID 0000-0002-3292-6671
Eike SteinmannDepartment for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.
Thomas PietschmannInstitute for Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany.ORCID 0000-0001-6789-4422
Center for Experimental and Clinical Infection Research · DERuhr University Bochum · DEUniversity of Würzburg · DECarl von Ossietzky Universität Oldenburg · DEMedizinische Hochschule Hannover · DEPaul Ehrlich Institut · DE

Funding

Genetic Viral and Host Adaptations to Breach Species Barriers of HCVR01AI107301 · NIAID · PRINCETON UNIVERSITY · PI Thomas Pietschmann, Alexander Ploss · 2013 to 2026
$6.0M
NIAID NIH HHS R01 AI107301
6 · The paper itself

Abstract

Mice are refractory to infection with human-tropic hepatitis C virus (HCV), although distantly related rodent hepaciviruses (RHV) circulate in wild rodents. To investigate whether liver intrinsic host factors can exhibit broad restriction against these distantly related hepaciviruses, we focused on Shiftless (

Indexed as

HepacivirusHepatitis CAnimalsAntiviral AgentsAntiviral Restriction FactorsHumansInterferonsMiceAntiviral AgentsAntiviral Restriction FactorsInterferonsHCVhepatitis C virusIFNliverrestriction factorspecies tropismvirus

Identifiers

PMID37341610
PMCPMC10433982
OpenAlexW4381470498

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.