Evidence map›Paper›PMID 37341543›Full record

ArticleThe Journal of infectious diseases2023

Antibody to Plasmodium falciparum Variant Surface Antigens, var Gene Transcription, and ABO Blood Group in Children With Severe or Uncomplicated Malaria.

Priyanka Barua, Michael F Duffy, Laurens Manning, Moses Laman, Timothy M E Davis, Ivo Mueller, Ali Haghiri, Julie A Simpson, James G Beeson, Stephen J Rogerson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Priyanka BaruaDepartment of Medicine, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne.
Michael F DuffyDepartment of Medicine, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne.
Laurens ManningMedical School, University of Western Australia, Perth.ORCID 0000-0003-4334-5351
Moses LamanVector Borne Diseases Unit, Papua New Guinea Institute of Medical Research, Madang.
Timothy M E DavisMedical School, University of Western Australia, Perth.
Ivo MuellerPopulation Health and Immunity, Walter and Eliza Hall Institute, Parkville, Victoria, Australia.
Ali HaghiriCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville.
Julie A SimpsonCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville.
James G BeesonMalaria Immunity and Vaccines Laboratory, Burnet Institute, Melbourne.ORCID 0000-0002-1018-7898
Stephen J RogersonDepartment of Medicine, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne.ORCID 0000-0003-4287-1982
The University of Melbourne · AUThe University of Western Australia · AUBurnet Institute · AUInstitut Pasteur · FRPapua New Guinea Institute of Medical Research · PG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntibodies to variant surface antigens (VSAs) such as Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) may vary with malaria severity. The influence of ABO blood group on antibody development is not understood.

methodsImmunoglobulin G antibodies to VSAs in Papua New Guinean children with severe (n = 41) or uncomplicated (n = 30) malaria were measured by flow cytometry using homologous P falciparum isolates. Isolates were incubated with ABO-matched homologous and heterologous acute and convalescent plasma. RNA was used to assess var gene transcription.

resultsAntibodies to homologous, but not heterologous, isolates were boosted in convalescence. The relationship between antibody and severity varied by blood group. Antibodies to VSAs were similar in severe and uncomplicated malaria at presentation, higher in severe than uncomplicated malaria in convalescence, and higher in children with blood group O than other children. Six var gene transcripts best distinguished severe from uncomplicated malaria, including UpsA and 2 CIDRα1 domains.

conclusionsABO blood group may influence antibody acquisition to VSAs and susceptibility to severe malaria. Children in Papua New Guinea showed little evidence of acquisition of cross-reactive antibodies following malaria. Var gene transcripts in Papua New Guinean children with severe malaria were similar to those reported from Africa.

Indexed as

MalariaMalaria, FalciparumABO Blood-Group SystemAntibodies, ProtozoanAntigens, ProtozoanAntigens, SurfaceChildConvalescenceHumansPlasmodium falciparumProtozoan ProteinsTranscription, GeneticABO Blood-Group SystemAntibodies, ProtozoanAntigens, ProtozoanAntigens, SurfaceProtozoan ProteinsPapua New GuineapfEMP1severe malariavar genesvariant surface antigen

Identifiers

PMID37341543
PMCPMC10582907
OpenAlexW4381469736

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.