Evidence map›Paper›PMID 37341389›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2023

Design, synthesis, and antitumor efficacy of novel 5-deazaflavin derivatives backed by kinase screening, docking, and ADME studies.

Walaa A Bedewy, Mosaad S Mohamed, Ahmed M Abdelhameed, Mohamed A Elsawy, Mohammed Al-Muhur, Noriyuki Ashida, Ashraf N Abdalla, Tamer A Elwaie, Tomohisa Nagamatsu, Hamed I Ali

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Walaa A BedewyPharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Helwan, Egypt.
Mosaad S MohamedPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Helwan, Egypt.
Ahmed M AbdelhameedPharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Helwan, Egypt.
Mohamed A ElsawyLeicester Institute of Pharmaceutical Innovation, Leicester School of Pharmacy, De Monfort University, Leicester, UK.
Mohammed Al-MuhurDoctor Suliman Al Habib Hospital, Riyadh, Saudi Arabia.
Noriyuki AshidaBiology Laboratory, Research and Development Division, Yamasa Co., Chiba, Japan.
Ashraf N AbdallaDepartment of Pharmacology and Toxicology, Pharmacy College, Umm Al-Qura University, Makkah, Saudi Arabia.
Tamer A ElwaieDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Tomohisa NagamatsuFaculty of Pharmacological Sciences, Laboratory of Curative Creation Study for Geriatric-diseases Prevention, Sojo University, Kumamoto, Japan.
Hamed I AliDepartment of Pharmaceutical Sciences, Irma Lerma Rangel School of Pharmacy, Texas A&M University, College Station, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Novel 5-deazaflavins were designed as potential anticancer candidates. Compounds

Indexed as

EthanolamineEthanolaminesFlavinsHeLa CellsHumans5-deazaflavinEthanolamineEthanolaminesFlavins5-DeazaflavinADMEantitumorkinase profilingmolecular docking

Identifiers

PMID37341389
PMCPMC10286681

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.