Evidence map›Paper›PMID 37341384›Full record

ArticleAnalytical chemistry2023

Distinguishing Oligosaccharide Isomers Using Far-Infrared Ion Spectroscopy: Identification of Biomarkers for Inborn Errors of Metabolism.

Rianne E van Outersterp, Pieter C Kooijman, Jona Merx, Udo F H Engelke, Nematollah Omidikia, Mei-Lan H Tonneijck, Kas J Houthuijs, Giel Berden, Tessa M A Peters, Dirk J Lefeber and 8 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 2 countries.

Rianne E van OutersterpInstitute for Molecules and Materials, FELIX Laboratory, Radboud University, 6525 ED Nijmegen, The Netherlands.ORCID 0000-0001-7493-2765
Pieter C KooijmanInstitute for Molecules and Materials, FELIX Laboratory, Radboud University, 6525 ED Nijmegen, The Netherlands.
Jona MerxInstitute for Molecules and Materials, Synthetic Organic Chemistry, Radboud University, 6525 AJ Nijmegen, The Netherlands.
Udo F H EngelkeDepartment of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands.
Nematollah OmidikiaDepartment of Analytical Chemistry and Chemometrics, Institute for Molecules and Materials, Radboud University, 6525 AJ Nijmegen, The Netherlands.ORCID 0000-0003-0359-0213
Mei-Lan H TonneijckInstitute for Molecules and Materials, FELIX Laboratory, Radboud University, 6525 ED Nijmegen, The Netherlands.
Kas J HouthuijsInstitute for Molecules and Materials, FELIX Laboratory, Radboud University, 6525 ED Nijmegen, The Netherlands.ORCID 0000-0002-8205-2896
Giel BerdenInstitute for Molecules and Materials, FELIX Laboratory, Radboud University, 6525 ED Nijmegen, The Netherlands.ORCID 0000-0003-1500-922X
Tessa M A PetersDepartment of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-5021-2955
Dirk J LefeberDepartment of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands.
Michel A A P WillemsenAmalia Children's Hospital, Department of Pediatric Neurology & Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.
Jasmin MecinovicDepartment of Physics, Chemistry and Pharmacy, University of Southern Denmark, 5230 Odense, Denmark.ORCID 0000-0002-5559-3822
Jeroen J JansenDepartment of Analytical Chemistry and Chemometrics, Institute for Molecules and Materials, Radboud University, 6525 AJ Nijmegen, The Netherlands.
Karlien L M CoeneDepartment of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands.
Ron A WeversDepartment of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands.
Thomas J BoltjeInstitute for Molecules and Materials, Synthetic Organic Chemistry, Radboud University, 6525 AJ Nijmegen, The Netherlands.
Jos OomensInstitute for Molecules and Materials, FELIX Laboratory, Radboud University, 6525 ED Nijmegen, The Netherlands.ORCID 0000-0002-2717-1278
Jonathan MartensInstitute for Molecules and Materials, FELIX Laboratory, Radboud University, 6525 ED Nijmegen, The Netherlands.ORCID 0000-0001-9537-4117
Radboud University Nijmegen · NLUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Distinguishing isomeric saccharides poses a major challenge for analytical workflows based on (liquid chromatography) mass spectrometry (LC-MS). In recent years, many studies have proposed infrared ion spectroscopy as a possible solution as the orthogonal, spectroscopic characterization of mass-selected ions can often distinguish isomeric species that remain unresolved using conventional MS. However, the high conformational flexibility and extensive hydrogen bonding in saccharides cause their room-temperature fingerprint infrared spectra to have broad features that often lack diagnostic value. Here, we show that room-temperature infrared spectra of ion-complexed saccharides recorded in the previously unexplored far-infrared wavelength range (300-1000 cm

Indexed as

Metabolism, Inborn ErrorsOligosaccharidesBiomarkersHumansIonsIsomerismMonosaccharidesSpectrophotometry, InfraredBiomarkersIonsMonosaccharidesOligosaccharides

Identifiers

PMID37341384
PMCPMC10323868
OpenAlexW4381470493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.