ArticleThe Journal of antimicrobial chemotherapy2023
One Health compartment analysis of ESBL-producing Escherichia coli reveals multiple transmission events in a rural area of Madagascar.
Article in The Journal of antimicrobial chemotherapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 21 citations in OpenAlex.
- Genomic epidemiology of extended-spectrum beta-lactamase-producingJAC-antimicrobial resistance · 2026Article
- Extended-Spectrum β-Lactamase-ProducingAnimals : an open access journal from MDPI · 2026Article
- Linking land use to the likely origins of third-generation cephalosporin-resistant Enterobacterales in freshwater.Applied and environmental microbiology · 2026Article
- Diverse Reservoirs of Third-Generation Cephalosporin-Resistant Escherichia coli in Guatemala.EcoHealth · 2026Article
- From clinics to sewers: leveraging environmental surveillance and whole genome sequencing to inform transmission of ESBL-Applied and environmental microbiology · 2026Article
- Transmission of extended spectrum β-lactamase-producing Escherichia coli and antimicrobial resistance gene flow across One Health compartments in eastern Africa: a whole-genome sequence analysis from a prospective cohort study.The Lancet. Microbe · 2026Article
- Extended-Spectrum Beta-Lactamase (ESBL)-Producing E. coli in Livestock and Free-Roaming Wildlife: A Combined Phenotyping-Whole-Genome Sequencing One Health Approach.Transboundary and emerging diseases · 2026Article
- Formal and informal antimicrobial trade and usage in farmed animals of the urban area of Lomé, Togo.One health (Amsterdam, Netherlands) · 2025Article
- A One Health Comparative Study of MDRAntibiotics (Basel, Switzerland) · 2025Article
- Extensive Overlap in Avian and Extraintestinal PathogenicAvian diseases · 2025Article
- Tracking Extended-Spectrum Beta Lactamase-ProducingOpen forum infectious diseases · 2025Article
- A systematic review of antimicrobial resistance transmission inferences at the human-livestock interface in Africa.npj antimicrobials and resistance · 2025Article
- Identification of ESBL-Producing Enterobacterales From Vegetable Plants: Preliminary Findings From a Small Cross-Sectional Study in a Rural Area of Madagascar.Environmental microbiology reports · 2025Article
- Genomic characterization of extended-spectrum β-lactamase-producingApplied and environmental microbiology · 2025Article
- Assessment of the environmental transmission dynamics ofOpen veterinary journal · 2025Article
- Detection of theOpen veterinary journal · 2025Article
- Overview of antimicrobial resistance mitigation efforts in Benin 2024.Journal of public health in Africa · 2025Article
- Limited clonality but widespread plasmid sharing of ESBL-producingCurrent research in microbial sciences · 2025Article
- Genetic Characterization, Transmission Pattern and Health Risk Analysis of Intestinal Colonization ESBL-ProducingMicroorganisms · 2024Article
- Aligning antimicrobial resistance surveillance with schistosomiasis research: an interlinked One Health approach.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2024Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundESBL-producing Escherichia coli (ESBL-Ec) is considered a key indicator for antimicrobial resistance (AMR) epidemiological surveillance in animal, human and environment compartments. There is likelihood of ESBL-Ec animal-human transmission but proof of cross-compartment transmission is still unclear.
objectivesTo characterize ESBL-Ec genetic similarity in various compartments (humans, animals and environment) from a rural area of Madagascar.
methodsWe collected ESBL-Ec isolates prospectively from humans, animals and the environment (water) between April and October 2018. These isolates were subject to WGS and analysed with cutting-edge phylogenomic methods to characterize population genetic structure and infer putative transmission events among compartments.
resultsOf the 1454 samples collected, 512 tested positive for ESBL-Ec. We successfully sequenced 510 samples, and a phylogenomic tree based on 179 365 SNPs was produced. Phylogenetic distances between and amongst compartments were indistinguishable, and 104 clusters of recent transmission events between compartments were highlighted. Amongst a large diversity of ESBL-Ec genotypes, no lineage host specificity was observed, indicating the regular occurrence of ESBL-Ec transfer among compartments in rural Madagascar.
conclusionsOur findings stress the importance of using a phylogenomic approach on ESBL-Ec samples in various putative compartments to obtain a clear baseline of AMR transmissions in rural settings, where one wants to identify risk factors associated with transmission or to measure the effect of 'One Health' interventions in low- and middle-income countries.
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