Evidence map›Paper›PMID 37341132›Full record

ReviewJournal of cell science2023

Viral evasion of the interferon response at a glance.

Junji Zhu, Cindy Chiang, Michaela U Gack

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of cell science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Current issues in molecular biology · 2026
    Review
  3. Review
  4. Review
  5. Article
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  11. Review
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  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Tearing down the house of mosquito-transmitted viruses.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Activation and Evasion of the FEAR Pathway by RNA Viruses.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Junji ZhuFlorida Research and Innovation Center , Cleveland Clinic, Port St. Lucie, FL 34987, USA.
Cindy ChiangFlorida Research and Innovation Center , Cleveland Clinic, Port St. Lucie, FL 34987, USA.
Michaela U GackFlorida Research and Innovation Center , Cleveland Clinic, Port St. Lucie, FL 34987, USA.ORCID 0000-0002-2163-2598
Cleveland Clinic Florida · US

Funding

Defining the viral PTMome: Towards the development of novel antiviral approachesDP1AI169444 · NIAID · CLEVELAND CLINIC LERNER COM-CWRU · PI GACK, MICHAELA ULRIKE · 2021 to 2025
$5.6M
Regulation of Host Innate Immunity Against Viral InfectionR01AI087846 · NIAID · UNIVERSITY OF CHICAGO · PI GACK, MICHAELA ULRIKE · 2010 to 2020
$3.9M
Regulation of Host Innate Immunity Against Viral InfectionR37AI087846 · NIAID · CLEVELAND CLINIC LERNER COM-CWRU · PI Michaela Ulrike Gack · 2021 to 2026
$2.8M
Novel Role for Host Immunostimulatory RNA in Antiviral Immune DefenseR01AI165502 · NIAID · CLEVELAND CLINIC LERNER COM-CWRU · PI GACK, MICHAELA ULRIKE · 2021 to 2025
$2.3M
The Role of TRIM23 in Autophagy Mediated Antiviral DefensesR01AI148534 · NIAID · UNIVERSITY OF CHICAGO · PI GACK, MICHAELA ULRIKE · 2020 to 2024
$2.3M
NIAID NIH HHS DP1 AI169444NIAID NIH HHS R01 AI087846NIAID NIH HHS R01 AI148534NIAID NIH HHS R01 AI165502NIAID NIH HHS R37 AI087846
6 · The paper itself

Abstract

Re-emerging and new viral pathogens have caused significant morbidity and mortality around the world, as evidenced by the recent monkeypox, Ebola and Zika virus outbreaks and the ongoing COVID-19 pandemic. Successful viral infection relies on tactical viral strategies to derail or antagonize host innate immune defenses, in particular the production of type I interferons (IFNs) by infected cells. Viruses can thwart intracellular sensing systems that elicit IFN gene expression (that is, RIG-I-like receptors and the cGAS-STING axis) or obstruct signaling elicited by IFNs. In this Cell Science at a Glance article and the accompanying poster, we review the current knowledge about the major mechanisms employed by viruses to inhibit the activity of intracellular pattern-recognition receptors and their downstream signaling cascades leading to IFN-based antiviral host defenses. Advancing our understanding of viral immune evasion might spur unprecedented opportunities to develop new antiviral compounds or vaccines to prevent viral infectious diseases.

Indexed as

COVID-19Interferon Type IZika VirusZika Virus InfectionAntiviral AgentsHumansImmune EvasionPandemicsAntiviral AgentsInterferon Type IInnate immunityInterferonIntracellular sensorsViral evasion

Identifiers

PMID37341132
PMCPMC10411950
OpenAlexW4381469512

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.