Evidence map›Paper›PMID 37340856›Full record

ArticleAmerican journal of Alzheimer's disease and other dementias

Associations of Telomere Length and Change With Cognitive Decline Were Modified by Sex and Race: The REGARDS Study.

Cheng Chen, Keming Yang, Hongmei Nan, Frederick Unverzagt, Leslie A McClure, Marguerite R Irvin, Suzanne Judd, Mary Cushman, Debora Kamin Mukaz, James E Klaunig and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of Alzheimer's disease and other dementias. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Shorter Telomere Length in Individuals with Neurocognitive Disorder andInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Cheng ChenDepartment of Obstetrics and Gynecology, Vagelos College of Physician and Surgeons, Columbia University, New York, NY, USA.
Keming YangClinical and Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital & Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Hongmei NanDepartment of Global Health, Richard M. Fairbanks School of Public Health, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.
Frederick UnverzagtDepartment of Psychiatry, School of Medicine, Indiana University, Indianapolis, IN, USA.
Leslie A McClureDepartment of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA, USA.
Marguerite R IrvinDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Suzanne JuddDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Mary CushmanDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT, USA.
Debora Kamin MukazDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT, USA.
James E KlaunigDepartment of Environmental and Occupational Health, School of Public Health, Indiana University-Bloomington, Bloomington, IN, USA.
Mary E D'AltonDepartment of Obstetrics and Gynecology, Vagelos College of Physician and Surgeons, Columbia University, New York, NY, USA.
Ka KaheDepartment of Obstetrics and Gynecology, Vagelos College of Physician and Surgeons, Columbia University, New York, NY, USA.ORCID 0000-0001-5078-2010
Columbia University · USIndiana University – Purdue University Indianapolis · USUniversity of Alabama at Birmingham · USUniversity of Vermont · USDrexel University · USHarvard University · USIndiana University Bloomington · US

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Trace mineral levels, the trajectory of cognitive decline and telomere attritionRF1AG056111 · NIA · TRUSTEES OF INDIANA UNIVERSITY · PI KAHE, KA · 2017 to 2017
$3.1M
NIA NIH HHS RF1 AG056111NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

introductionWe examined the associations of baseline telomere length (TL) and TL change with cognitive function over time in older US adults, as well as differences by sex and race.

methodsA total of 1820 cognitively healthy individuals (median baseline age: 63 years) were included. Telomere length was measured using qPCR-based method at baseline and among 614 participants in the follow-up examination 10 years later. Cognitive function was assessed by a four-test battery every 2 years.

resultsIn multivariable-adjusted linear mixed models, longer baseline TL and smaller attrition/lengthening of TL over time were associated with better Animal Fluency Test score. Longer baseline TL was also linearly associated with better Letter Fluency Test score. The observed associations were consistently more pronounced in women than men and in Black compared to White participants. DISCUSSION: Telomere length may be a biomarker that predicts long-term verbal fluency and executive function, particularly in women and Black Americans.

Indexed as

CognitionCognitive DysfunctionBiomarkersExecutive FunctionFemaleHumansTelomereBiomarkerscognitive declineexecutive function, sex disparityracial disparitytelomere length

Identifiers

PMID37340856
PMCPMC10624094
OpenAlexW4381469249

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.