ArticleEnvironmental science & technology2023
Domestic Dogs and Horses as Sentinels of Per- and Polyfluoroalkyl Substance Exposure and Associated Health Biomarkers in Gray's Creek North Carolina.
Article in Environmental science & technology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Global Inventory of Fluoropolymer Production Plants and Their Associated PFAS Environmental Contamination.Environmental science & technology · 2026Article
- Recent advances and challenges of analytical methods for detection of perfluoroalkyl and polyfluoroalkyl substances.RSC advances · 2026Review
- An overview of the impact of PFAS on animals, humans, and the environment using a One Health approach.Environmental science and pollution research international · 2026Review
- Novel LC-MS/MS Method for Monitoring Perfluoroalkyl and Polyfluoroalkyl Substances in Companion Animal Blood Plasma and Serum: Environmental and Health Implications.International journal of veterinary science and medicine · 2026Article
- An investigation of per- and polyfluoroalkyl concentrations in dogs and cats with endocrine disorders.Frontiers in veterinary science · 2026Article
- Multiple contaminant detection in commercially available chicken-based cat kibbles in Italy.Frontiers in veterinary science · 2026Article
- Could the Risk of Chronic Degenerative Valve Disease (CDVD) in Dogs Depend on Exposure to Endocrine-Disrupting Chemicals Polluting the Environment?Animals : an open access journal from MDPI · 2025Article
- Changes in the levels and predictors of per- and poly-fluoroalkyl substances in maternal plasma, relative to timelines of EPA PFOA Stewardship.Environment international · 2025Article
- Reproductive Effects of Endocrine Disruptors in Domestic Ruminants: Integrating In Vitro and In Vivo Evidence.Animals : an open access journal from MDPI · 2025Review
- Review
- Novel PFAS in alligator blood discovered with non-targeted ion mobility spectrometry-mass spectrometry.The Science of the total environment · 2025Article
- Novel PFAS in Alligator Blood Discovered with Non-Targeted Ion Mobility Spectrometry-Mass Spectrometry.bioRxiv : the preprint server for biology · 2025Article
- Article
- Per- and polyfluoroalkyl substances in dog blood serum levels and semen quality.Frontiers in endocrinology · 2025Article
- Long-chain perfluoroalkylether carboxylic acids PFO5DoA and PFO4DA alter glucose, bile acid, and thyroid hormone homeostasis in fetal rats from 5-day maternal oral exposure.Environmental research · 2024Article
- Residential Garden Produce Harvested Near a Fluorochemical Manufacturer in North Carolina Can Be An Important Fluoroether Exposure Pathway.Journal of agricultural and food chemistry · 2024Article
- Exploring maternal and developmental toxicity of perfluoroalkyl ether acids PFO4DA and PFO5DoA using hepatic transcriptomics and serum metabolomics.The Science of the total environment · 2024Article
- Combined screening and retroactive data mining for emerging perfluoroethers in wildlife and pets in the Cape Fear region of North Carolina.Chemosphere · 2024Article
- Quantitative cross-species comparison of serum albumin binding of per- and polyfluoroalkyl substances from five structural classes.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Current Review of Increasing Animal Health Threat of Per- and Polyfluoroalkyl Substances (PFAS): Harms, Limitations, and Alternatives to Manage Their Toxicity.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Central North Carolina (NC) is highly contaminated with per- and polyfluoroalkyl substances (PFAS), in part due to local fluorochemical production. Little is known about the exposure profiles and long-term health impacts for humans and animals that live in nearby communities. In this study, serum PFAS concentrations were determined using liquid chromatography high-resolution mass spectrometry and diagnostic clinical chemistry endpoints were assessed for 31 dogs and 32 horses that reside in Gray's Creek NC at households with documented PFAS contamination in their drinking water. PFAS were detected in every sample, with 12 of the 20 PFAS detected in ≥50% of samples from each species. The average total PFAS concentrations in horses were lower compared to dogs who had higher concentrations of PFOS (dogs 2.9 ng/mL; horses 1.8 ng/mL), PFHxS (dogs 1.43 ng/mL, horses < LOD), and PFOA (dogs 0.37 ng/mL; horses 0.10 ng/mL). Regression analysis highlighted alkaline phosphatase, glucose, and globulin proteins in dogs and gamma glutamyl transferase in horses as potential biomarkers associated with PFAS exposure. Overall, the results of this study support the utility of companion animal and livestock species as sentinels of PFAS exposure differences inside and outside of the home. As in humans, renal and hepatic health in domestic animals may be sensitive to long-term PFAS exposures.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.