ArticleBMC psychiatry2023
The association between serum albumin and depressive symptoms: a cross-sectional study of NHANES data during 2005-2018.
Article in BMC psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 17 citations in OpenAlex.
- Association of the red blood cell distribution width-to-albumin ratio with incident depression and depressive symptom trajectories in older adults.European archives of psychiatry and clinical neuroscience · 2026Article
- Biological and Metabolic Correlates of Psychological Resilience in Maintenance Hemodialysis: An Exploratory Gender-Based Study.Medicina (Kaunas, Lithuania) · 2026Article
- The Impact of the CALLY Index on All-Cause Mortality in Patients With Depression: A Longitudinal Analysis Using NHANES Data.Health science reports · 2026Article
- L-shaped association between depressive symptoms and the number of close friends: A cross-sectional study.The Journal of international medical research · 2026Article
- Association of serum albumin and obesity: Mediation effect of extracellular fluid, percent body fat and C-reactive protein.Medicine · 2026Article
- Associations Between Controlling Nutritional Status and Allostatic Load With Heart Failure Across Different Depressive States: A Cross-Sectional Study Using NHANES 2005-2018 Data.Reviews in cardiovascular medicine · 2026Article
- Biochemical Associations with Depression, Anxiety, and Stress in Hemodialysis: The Role of Albumin, Calcium, and βBiomedicines · 2025Article
- Exploring the mechanism of methyl parathion and its degradation product on depression through network toxicology and molecular docking.Scientific reports · 2025Article
- NHANES 2005-2018 data reveal high albumin-bilirubin scores are associated with depression.BMC psychiatry · 2025Article
- Association between red blood cell distribution width-to-albumin ratio and depression: a cross-sectional analysis among US adults, 2011-2018.BMC psychiatry · 2025Article
- The mediating roles of obesity indicators and serum albumin in the association of DEET exposure with depression and sleep disorders in adults: evidence from NHANES 2007-2016.BMC public health · 2025Article
- Association between serum albumin levels and erectile dysfunction in American Adults: A cross-sectional study from NHANES 2001-2004.PloS one · 2025Article
- Association Between Neutrophil Percentage-to-Albumin Ratio and Depression in Middle-Aged and Elderly Adults: A National Study.Behavioural neurology · 2025Article
- Associations of a prognostic immune and nutritional index with all-cause and cause-specific mortality in individuals with depression: evidence from NHANES 2005-2018.Frontiers in nutrition · 2025Article
- Association of Neutrophil-Percentage-To-Albumin Ratio(NPAR) with depression symptoms in U.S. adults: a NHANES study from 2011 to 2018.BMC psychiatry · 2024Article
- Association between uric acid and the risk of depressive symptoms in US adults: results from NHANES 2005-2018.Scientific reports · 2024Article
- Association between nocturia and serum albumin in the U.S. adults from NHANES 2005-2012.PloS one · 2024Article
- Association between psychiatric symptoms with multiple peripheral blood sample test: a 10-year retrospective study.Frontiers in psychiatry · 2024Article
- Serum albumin levels and stress urinary incontinence in females: A retrospective study based on NHANES 2007-2016.Heliyon · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe association between serum albumin and depressive symptoms has been unclear in previous epidemiological studies. We explored whether serum albumin is associated with depressive symptoms based on the National Health and Nutrition Examination Survey (NHANES) data.
methodsThis cross-sectional study included 13,681 participants aged ≥ 20 years from the NHANES performed during 2005-2018, which produced nationally representative database. Depressive symptoms were assessed using the Patient Health Questionnaire-9. Serum albumin concentration was measured using the bromocresol purple dye method, and participants were divided into quartiles of serum albumin concentrations. Weighted data were calculated according to analytical guidelines. Logistics regression and linear regression models were used to assess and quantify the association between serum albumin and depressive symptoms. Univariate and stratified analyses were also performed.
resultsThere were 1551 (10.23%) adults (aged ≥ 20 years) with depressive symptoms among the 13,681. A negative association was found between serum albumin concentration and depressive symptoms. Compared with the lowest albumin quartile, the multivariate-adjusted effect size (95% confidence interval) for depressive symptoms of the fully adjusted model in the highest albumin quartile was 0.77 (0.60 to 0.99) and - 0.38 (- 0.66 to - 0.09) using logistics regression and linear regression models respectively. Current smoking status modified the association between serum albumin concentration and PHQ-9 scores (p for interaction = 0.033).
conclusionThis cross-sectional study revealed that albumin concentration is significantly more likely to be a protective factor for depressive symptoms, with the association being more pronounced in non-smokers.
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