Evidence map›Paper›PMID 37340287›Full record

ArticleEndocrine2023

Effects of successful parathyroidectomy on neuropsychological and cognitive status in patients with asymptomatic primary hyperparathyroidism.

Milan Jovanovic, Vladan Zivaljevic, Sandra Sipetic Grujicic, Katarina Tausanovic, Nikola Slijepcevic, Branislav Rovcanin, Ksenija Jovanovic, Bozidar Odalovic, Matija Buzejic, Zoran Bukumiric and 1 more

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Article in Endocrine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Milan JovanovicClinic for Endocrine Surgery, University Clinical Center of Serbia, Belgrade, Serbia. milanjovanovicceh@gmail.com.ORCID 0000-0002-0118-8450
Vladan ZivaljevicClinic for Endocrine Surgery, University Clinical Center of Serbia, Belgrade, Serbia.
Sandra Sipetic GrujicicInstitute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Katarina TausanovicClinic for Endocrine Surgery, University Clinical Center of Serbia, Belgrade, Serbia.
Nikola SlijepcevicClinic for Endocrine Surgery, University Clinical Center of Serbia, Belgrade, Serbia.
Branislav RovcaninClinic for Endocrine Surgery, University Clinical Center of Serbia, Belgrade, Serbia.
Ksenija JovanovicFaculty of Medicine, University of Belgrade, Belgrade, Serbia.
Bozidar OdalovicClinic for Endocrine Surgery, University Clinical Center of Serbia, Belgrade, Serbia.
Matija BuzejicClinic for Endocrine Surgery, University Clinical Center of Serbia, Belgrade, Serbia.
Zoran BukumiricInstitute of Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Ivan PaunovicClinic for Endocrine Surgery, University Clinical Center of Serbia, Belgrade, Serbia.
University of Belgrade · RS

Funding

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja 175042
6 · The paper itself

Abstract

purposeBesides typical clinical symptoms, primary hyperparathyroidism (pHPT) is associated with impaired quality of life and cognitive status. The aim of this study was to evaluate the quality of life and cognitive impairment in patients with pHPT, before and after parathyroidectomy.

methodsWe conducted a panel study, which included asymptomatic pHPT patients scheduled for parathyroidectomy. Besides demographic and clinical data, patients' quality of life and cognitive capacity were recorded before, 1 month, and 6 months following parathyroidectomy using the Short Form 36 questionnaire (RAND-36), Beck Depression Inventory (BDI), Depression Anxiety Stress Scales (DASS), Mini-Mental State Examination (MMSE), and Symptom Check List 90-revised version (SCL90R).

resultsDuring a 2-year follow-up, 101 patients entered the study (88 women), with an average age of 60.7 years. The Global score of RAND-36 test ameliorated by almost 50% 6 months after parathyroidectomy. The most sustained subscores of the RAND-36 test were role functioning/physical and health change, with an improvement of more than 125%. According to the BDI, DASS depression subscore, and SCL90R depression subscore, the extent of depressive symptoms reduction was approximately 60% 6 months postoperatively. The level of anxiety was reduced by 62.4%, measured by both the DASS and SCL90R anxiety subscores. The stress level was almost halved according to the DASS stress subscore (from 10.7 to 5.6 points). The results of the MMSE test showed a significant improvement postoperatively, for 1.2 points (4.4%). A worse preoperative score of each tool was related to the higher magnitude of improvement 6 months after parathyroidectomy.

conclusionA considerable number of pHPT patients, even without other typical symptoms, show signs of impaired quality of life and neurocognitive status preoperatively. After a successful parathyroidectomy, there is an improvement in quality of life, declined levels of depression, anxiety, and stress, as well as amelioration of cognitive status. Patients with more impaired quality of life and pronounced neurocognitive symptoms may expect more benefits from the surgery.

Indexed as

Hyperparathyroidism, PrimaryParathyroidectomyCognitionDepressionFemaleHumansMiddle AgedProspective StudiesQuality of LifeCognitive statusParathyroidectomyPrimary hyperparathyroidismQuality of life

Identifiers

PMID37340287
OpenAlexW4381469275

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.