ArticleEndocrine2024
Abnormal cerebral blood flow and brain function in type 2 diabetes mellitus.
Article in Endocrine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Structural and functional brain abnormal alteration in patients with type 2 diabetes mellitus: A coordinate-based meta-analysis.Translational psychiatry · 2025Pooled it
- Diabetic cerebral microvascular disorder: from key pathologies to targeted interventions.Annals of medicine · 2026Review
- Effects of a high-sugar mixed meal on cerebrovascular haemodynamics in young, healthy versus middle-aged adults with cardiometabolic risk factors.Experimental physiology · 2026Article
- A Multimodal MRI Study of the White Matter Microstructural and Hemodynamic Underpinnings of Cognitive Decline in Type 2 Diabetes Mellitus.Brain topography · 2026Article
- Prediction of acute metabolic complications in hospitalized elderly patients with type 2 diabetes using admission HbA1c and hypertension: a retrospective cohort study.American journal of translational research · 2026Article
- Ketogenic metabolic therapy: low-carbohydrate interventions as novel neuroprotective strategies for cognitive dysfunction in diabetes.Frontiers in aging neuroscience · 2026Review
- Functional MRI Analysis of Brain Activity in Rats With Diabetic Bladder Dysfunction.CNS neuroscience & therapeutics · 2025Article
- Cognitive functions among school-going children and adolescents with type 1 diabetes mellitus: Matched case-control cross-sectional study.Saudi medical journal · 2024Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
purposeType 2 diabetes mellitus (T2DM) lead to impaired cerebral blood perfusion, which leads to changes in brain function and affects the cognitive function of patients. In this study, cerebral blood flow (CBF) was used to evaluate the effect of T2DM on cerebral perfusion, and functional connectivity (FC) analysis was further used to explore whether the FC between the abnormal CBF region and the whole brain was changed. In addition, amplitude of low-frequency fluctuation (ALFF) and degree centrality (DC) were used to investigate the changes in spontaneous activity and connectivity strength of the brain network.
methodsWe recruited 40 T2DM patients and 55 healthy controls (HCs). They underwent 3D-T1WI, rs-fMRI, arterial spin labeling (ASL) sequence scans and a series of cognitive tests. Cognitive test scores and brain imaging indicators were compared between the two groups, and the relationships among laboratory indicators, cognitive test scores, and brain imaging indicators were explored in the T2DM group.
resultsCompared to HCs, The CBF values of Calcarine_L and Precuneus_R in the T2DM group were lower. The DC value of Paracentral_Lobule_L and Precuneus_L, and the ALFF value of Hippocampus_L in the T2DM group were higher. In addition, the CBF values of Calcarine_L was negatively correlated with fasting insulin and HOMA_IR.
conclusionThis study found that there were regions of cerebral hypoperfusion in T2DM patients, which are associated with insulin resistance. In addition, we found abnormally elevated brain activity and enhanced functional connectivity in T2DM patients, which we speculated was the compensatory mechanism of brain neural activity.
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