ArticleBJOG : an international journal of obstetrics and gynaecology2024
Trends and patterns of antiseizure medication prescribing during pregnancy between 1995 and 2018 in the United Kingdom: A cohort study.
Article in BJOG : an international journal of obstetrics and gynaecology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exposure to anti-seizure medication during pregnancy and the risk of autism and ADHD in offspring: a systematic review and meta-analysis.Frontiers in neurology · 2024Pooled it
- Development of cerebral lateralization in children exposed to fetal antiseizure medications: A prospective cohort study at age 6 years.Epilepsia · 2026Article
- Lithium prescribing in the perinatal period: UK primary care cohort study.The British journal of psychiatry : the journal of mental science · 2026Article
- Late Pregnancy Antiseizure Medication Exposure and Offspring Neurodevelopmental Risk: A Multi-Child Cohort Study.Annals of neurology · 2026Article
- Lamotrigine serum concentrations as longitudinal biomarkers for seizure risk prediction in pregnant women with epilepsy: a secondary analysis of the EMPiRE study.BMJ neurology open · 2026Article
- Transferrin-phosphatidylserine liposomes target TDP-43 and neuroinflammation in male mice with neuropathic pain.Nature communications · 2025Article
- Trends in Prenatal Exposure to Antiseizure Medications Over the Past Decade: A Nationwide Study.Neurology · 2025Article
- Trends in use of antiseizure medication and treatment pattern during the first trimester in the German Embryotox cohort.Scientific reports · 2024Article
- Antiseizure medication use during pregnancy and children's neurodevelopmental outcomes.Nature communications · 2024Article
- First-trimester use of antiseizure medications and the risk of miscarriage: a population-based cohort study.Journal of neurology, neurosurgery, and psychiatry · 2024Article
- Trends of antiseizure medication utilization among pregnant people in four Canadian provinces from 1998 to 2023; a study from the Canadian mother-child cohort active surveillance initiative (CAMCCO).Frontiers in pharmacology · 2024Article
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Authors and funding
13 authors.
Funding
Abstract
objectiveTo examine antiseizure medication (ASM) prescription during pregnancy.
designPopulation-based drug utilisation study.
settingUK primary and secondary care data, 1995-2018, from the Clinical Practice Research Datalink GOLD version. POPULATION OR SAMPLE: 752 112 completed pregnancies among women registered for a minimum of 12 months with an 'up to standard' general practice prior to the estimated start of pregnancy and for the duration of their pregnancy.
methodsWe described ASM prescription across the study period, overall and by ASM indication, examined patterns of prescription during pregnancy including continuous prescription and discontinuation, and used logistic regression to investigate factors associated with those ASM prescription patterns.
main outcome measuresPrescription of ASMs during pregnancy and discontinuation of ASMs before and during pregnancy.
resultsASM prescription during pregnancy increased from 0.6% of pregnancies in 1995 to 1.6% in 2018, driven largely by an increase in women with indications other than epilepsy. Epilepsy was an indication for 62.5% of pregnancies with an ASM prescription and non-epilepsy indications were present for 66.6%. Continuous prescription of ASMs during pregnancy was more common in women with epilepsy (64.3%) than in women with other indications (25.3%). Switching ASMs was infrequent (0.8% of ASM users). Factors associated with discontinuation included age ≥35, higher social deprivation, more frequent contact with the GP and being prescribed antidepressants or antipsychotics.
conclusionsASM prescription during pregnancy increased between 1995 and 2018 in the UK. Patterns of prescription around the pregnancy period vary by indication and are associated with several maternal characteristics.
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