Evidence map›Paper›PMID 37340192›Full record

ArticleAmino acids2023

Acetyl group for proper protection of β-sugar-amino acids used in SPPS.

István Varga, Viktória Goldschmidt Gőz, István Pintér, Antal Csámpai, András Perczel

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Amino acids, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

István VargaLaboratory of Structural Chemistry and Biology, Institute of Chemistry, Eötvös Loránd University, Pázmány P. Stny. 1/A, Budapest, 1117, Hungary.
Viktória Goldschmidt GőzELKH-ELTE Protein Modeling Research Group, Pázmány P. Stny. 1/A, Budapest, 1117, Hungary.
István PintérLaboratory of Structural Chemistry and Biology, Institute of Chemistry, Eötvös Loránd University, Pázmány P. Stny. 1/A, Budapest, 1117, Hungary.
Antal CsámpaiOrganic Chemistry Department, Eötvös Loránd University, Pázmány P. Stny. 1/A, Budapest, 1117, Hungary.
András PerczelLaboratory of Structural Chemistry and Biology, Institute of Chemistry, Eötvös Loránd University, Pázmány P. Stny. 1/A, Budapest, 1117, Hungary. perczel.andras@ttk.elte.hu.
Eötvös Loránd University · HU

Funding

ELTE Thematic Excellence Program (SzintPlus) TKP2020-NKA-06European Union's Recovery and Resilience Instrument (PharmaLab) RRF-2.3.1-21-2022-00015National Research, Development, and Innovation Fund of Hungary (HunProtExc) 2018-1.2.1-NKP-2018-00005
6 · The paper itself

Abstract

The synthesis of D-glucosamine-1-carboxylic acid based β-sugar amino acids (β-SAAs) is typically performed in nine consecutive steps via an inefficient OAc → Br → CN conversion protocol with low overall yield. Here, we present the improved and more efficient synthesis of both Fmoc-GlcAPC-OH and Fmoc-GlcAPC(Ac)-OH, β-SAAs consisting of only 4-5 synthetic steps. Their active ester and amide bond formation with glycine methyl ester (H-Gly-OMe) was completed and monitored by

Indexed as

Amino AcidsSugarsBlood ProteinsCarbohydratesFluorenesPeptidesAmino AcidsBlood ProteinsCarbohydratesFluorenesPeptidesstable plasma protein solutionSugarsChimera/foldamerCleavage protocolsSolid-phase peptide synthesisSugar amino acids

Identifiers

PMID37340192
PMCPMC10514111
OpenAlexW4381469749

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.