ArticleJournal of cancer research and clinical oncology2023
The different clonal origins of metachronous and synchronous metastases.
Article in Journal of cancer research and clinical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Metachronous solitary metastasis from left testicle seminoma presenting as a large intracranial tumor 4 years post-treatment: a case report and review of the literature.Journal of medical case reports · 2026Review
- Article
- Metastasis development in non-muscle-invasive bladder cancer.Nature reviews. Urology · 2025Review
- The Clonal Trajectory of Liver and Lung Metastases in Pancreatic Ductal Adenocarcinoma.Cancer reports (Hoboken, N.J.) · 2025Article
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8 authors.
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Abstract
backgroundMetastases are the leading cause of mortality in cancer patients. Linear and parallel are the two prominent models of metastatic progression. Metastases can be detected synchronously along with the primary tumor or metachronously, following treatment of localized disease. The aim of the study was to determine whether synchronous metastases (SM) and metachronous metastases (MM) differ only in lead-time or stem from different biological processes. MATERIALS AND
methodsWe retrospectively studied the chest CTs of 791 patients inflicted by eleven malignancy types that were treated in our institution in the years 2010-2020. Patient's population included 396 with SM and 395 with MM. The diameter of 15,427 lung metastases was measured. Clonal origin was deduced from the linear/parallel ratio (LPR)-a computerized analysis of metastases diameters. LPR of 1 suggests pure linear dissemination and - 1 pure parallel.
resultsPatients with MM were significantly older (average of 62.9 vs 60.7 years, p = 0.02), and higher percentage of them were males (58.7% vs 51.1%, p = 0.03). Median overall survival of patients with MM and SM was remarkably similar (23 months and 26 months respectively, p = 0.774) when calculated from the time of metastases diagnosis. Parallel dissemination (LPR ≤ 0) was found in 35.4% of patients with MM compared to only 19.8% of the patients with SM (p < 0.00001).
conclusionPatients with SM and MM differ in demography and in clonal origin. Different therapeutic approaches may be considered in these two conditions.
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