Evidence map›Paper›PMID 37340101›Full record

ArticlePediatric research2023

Interaction of hydrocortisone and illness severity on head growth in cohort of ELBW infants.

Haiwen Chen, Khyzer B Aziz, Harisa Spahic, Sarah Miller, Melike Guryildirim, Austin Sellers, Sandra Brooks, Alison Kilborn, Allen D Everett, Frances J Northington and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Haiwen Chen *Division of Pediatric Neurology, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Khyzer B Aziz *Division of Neonatology - Neuroscience Intensive Care Nursery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Harisa SpahicDivision of Neonatology - Neuroscience Intensive Care Nursery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sarah MillerDivision of Neonatology - Neuroscience Intensive Care Nursery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Melike GuryildirimDivision of Pediatric Neuroradiology, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Austin SellersDivision of Neonatology, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA.
Sandra BrooksDivision of Neonatology, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA.
Alison KilbornDivision of Neonatology - Neuroscience Intensive Care Nursery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Allen D EverettDivision of Pediatric Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Frances J NorthingtonDivision of Neonatology - Neuroscience Intensive Care Nursery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Carl E StafstromDivision of Pediatric Neurology, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Raul Chavez-ValdezDivision of Neonatology - Neuroscience Intensive Care Nursery, Johns Hopkins University School of Medicine, Baltimore, MD, USA. rchavez2@jhmi.edu.
Johns Hopkins Medicine · USJohns Hopkins University · USJohns Hopkins All Children's Hospital · US

Funding

Imaging Neonatal Hypoxic Ischemic InjuryR01HD074593 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FRANCES J NORTHINGTON, JIANGYANG ZHANG · 2013 to 2026
$6.8M
Adult Biomarkers in Neonatal Brain Injury and DevelopmentR01HD086058 · NICHD · JOHNS HOPKINS UNIVERSITY · PI EVERETT, ALLEN D, NORTHINGTON, FRANCES J · 2016 to 2020
$3.1M
Advanced therapeutic hypothermia efficacy network modeling in neonatal HIER01HD110091 · NICHD · JOHNS HOPKINS UNIVERSITY · PI EVERETT, ALLEN D, NORTHINGTON, FRANCES J · 2022 to 2025
$2.7M
Assessment of Brain Oxygen Consumption in Neonates using MRIR01NS109029 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI LIU, PEIYING · 2018 to 2023
$2.4M
Mechanisms of Hypothermic Neuroprotection in NeonatesR01HD070996 · NICHD · JOHNS HOPKINS UNIVERSITY · PI NORTHINGTON, FRANCES J · 2012 to 2016
$1.7M
Injury of Hippocampal Interneurons following Neonatal Hypoxia-Ischemia and Therapeutic HypothermiaK08NS096115 · NINDS · JOHNS HOPKINS UNIVERSITY · PI CHAVEZ-VALDEZ, RAUL · 2017 to 2021
$1.2M
Early Life Brain Injury and Neurodegenerative Disorders of AgingR21AG061643 · NIA · JOHNS HOPKINS UNIVERSITY · PI NORTHINGTON, FRANCES J · 2019 to 2020
$459k
NIA NIH HHS R21 AG061643NICHD NIH HHS R01 HD070996NICHD NIH HHS R01 HD074593NICHD NIH HHS R01 HD086058NICHD NIH HHS R01 HD110091NINDS NIH HHS K08 NS096115NINDS NIH HHS R01 NS109029
6 · The paper itself

Abstract

backgroundExtremely low birth weight (ELBW) infants comprise a fragile population at risk for neurodevelopmental disabilities (NDD). Systemic steroids were previously associated with NDD, but more recent studies suggest hydrocortisone (HCT) may improve survival without increasing NDD. However, the effects of HCT on head growth adjusted for illness severity during NICU hospitalization are unknown. Thus, we hypothesize that HCT will protect head growth, accounting for illness severity using a modified neonatal Sequential Organ Failure Assessment (M-nSOFA) score.

methodsWe conducted a retrospective study that included infants born at 23-29 weeks gestational age (GA) and < 1000 g. Our study included 73 infants, 41% of whom received HCT.

resultsWe found negative correlations between growth parameters and age, similar between HCT and control patients. HCT-exposed infants had lower GA but similar normalized birth weights; HCT-exposed infants also had higher illness severity and longer lengths of hospital stay. We found an interaction between HCT exposure and illness severity on head growth, such that infants exposed to HCT had better head growth compared to those not exposed to HCT when adjusted for illness severity.

conclusionThese findings emphasize the importance of considering patient illness severity and suggest that HCT use may offer additional benefits not previously considered. IMPACT: This is the first study to assess the relationship between head growth and illness severity in extremely preterm infants with extremely low birth weights during their initial NICU hospitalization. Infants exposed to hydrocortisone (HCT) were overall more ill than those not exposed, yet HCT exposed infants had better preserved head growth relative to illness severity. Better understanding of the effects of HCT exposure on this vulnerable population will help guide more informed decisions on the relative risks and benefits for HCT use.

Indexed as

HydrocortisoneInfant, Extremely Low Birth WeightHumansInfantInfant, NewbornInfant, PrematurePatient AcuityRetrospective StudiesHydrocortisone

Identifiers

PMID37340101
PMCPMC11210266
OpenAlexW4381332817

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.