ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023
Two Ascending Thermosensory Pathways from the Lateral Parabrachial Nucleus That Mediate Behavioral and Autonomous Thermoregulation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 26 citations in OpenAlex.
- Anesthesia unconsciousness recruits dynamic parabrachial activity within a distributed brain-wide ensemble.bioRxiv : the preprint server for biology · 2026Article
- Parabrachial neurons orchestrate cold-induced homeostatic responses.Nature metabolism · 2026Article
- Cold sensing and the parabrachial nucleus.Nature metabolism · 2026Article
- Neural Control of Homeothermy, Torpor, and Hibernation.Annual review of neuroscience · 2026Review
- Behavioral thermoregulation in relation to humidity in wild Japanese macaques (Macaca fuscata yakui): the significance of semi-shade.Primates; journal of primatology · 2026Article
- Intersectional expression ofAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Neural correlates of adversity-overcoming pup rescue behavior in female mice.Scientific reports · 2026Article
- The pyrogenic mediator prostaglandin EThe Journal of physiology · 2026Article
- Alcohol and substance use in extreme environment temperatures exposures, neural mechanisms, coping mechanisms, substance use disorders, and increased hospital visits.Frontiers in human neuroscience · 2026Review
- Behavioral and circuit principles of temperature gradient navigation.Current biology : CB · 2025Article
- Daily Household Electricity Consumption in Community-Dwelling Older Individuals With Cognitive Impairment: Prospective Cohort Study.JMIR formative research · 2025Article
- ParabrachialiScience · 2025Article
- The posterior capsular central amygdala showing synaptic coactivation with nociplastic pain-associated parabrachial neurons in mice.iScience · 2025Article
- Ictal cold shiver caused by autoimmune limbic encephalitis: A case report and literature review.Epilepsy & behavior reports · 2025Article
- Hypothalamic Vasopressin Neurons Enable Maternal Thermoregulatory Behaviors.bioRxiv : the preprint server for biology · 2025Article
- History and future of leptin: Discovery, regulation and signaling.Metabolism: clinical and experimental · 2024Review
- Thermoregulatory pathway underlying the pyrogenic effects of prostaglandin EActa pharmacologica Sinica · 2024Article
- Vertebrate behavioral thermoregulation: knowledge and future directions.Neurophotonics · 2024Review
- Burning Question: How Does Our Brain Process Positive and Negative Cues Associated with Thermosensation?Physiology (Bethesda, Md.) · 2024Review
- Hypothalamic Neuromodulation and Control of the Dermal Surface Temperature of Livestock during Hyperthermia.Animals : an open access journal from MDPI · 2024Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thermoregulatory behavior in homeothermic animals is an innate behavior to defend body core temperature from environmental thermal challenges in coordination with autonomous thermoregulatory responses. In contrast to the progress in understanding the central mechanisms of autonomous thermoregulation, those of behavioral thermoregulation remain poorly understood. We have previously shown that the lateral parabrachial nucleus (LPB) mediates cutaneous thermosensory afferent signaling for thermoregulation. To understand the thermosensory neural network for behavioral thermoregulation, in the present study, we investigated the roles of ascending thermosensory pathways from the LPB in avoidance behavior from innocuous heat and cold in male rats. Neuronal tracing revealed two segregated groups of LPB neurons projecting to the median preoptic nucleus (MnPO), a thermoregulatory center (LPB→MnPO neurons), and those projecting to the central amygdaloid nucleus (CeA), a limbic emotion center (LPB→CeA neurons). While LPB→MnPO neurons include separate subgroups activated by heat or cold exposure of rats, LPB→CeA neurons were only activated by cold exposure. By selectively inhibiting LPB→MnPO or LPB→CeA neurons using tetanus toxin light chain or chemogenetic or optogenetic techniques, we found that LPB→MnPO transmission mediates heat avoidance, whereas LPB→CeA transmission contributes to cold avoidance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.