Evidence map›Paper›PMID 37339849›Full record

ArticleGut2023

The first international Rome consensus conference on gut microbiota and faecal microbiota transplantation in inflammatory bowel disease.

Loris Riccardo Lopetuso, Sara Deleu, Lihi Godny, Valentina Petito, Pierluigi Puca, Federica Facciotti, Harry Sokol, Gianluca Ianiro, Luca Masucci, Maria Abreu and 15 more

Open access · hybridAbstract readConsensus Statement
In one paragraph

Article in Gut, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 2 pooled it
21.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 2 syntheses or guidelines pooled it, 111 citations in OpenAlex.

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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 15 institutions in 8 countries.

Loris Riccardo Lopetuso *IBD Unit, CEMAD Centro Malattie dell'Apparato Digerente, UOC di Medicina Interna e Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy lopetusoloris@gmail.com.ORCID 0000-0002-5747-2055
Sara Deleu *Department of Chronic Diseases & Metabolism (CHROMETA), KU Leuven, Leuven, Belgium.
Lihi GodnyDivision of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel.ORCID 0000-0001-7758-6466
Valentina PetitoIBD Unit, CEMAD Centro Malattie dell'Apparato Digerente, UOC di Medicina Interna e Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.ORCID 0000-0003-4396-1613
Pierluigi PucaIBD Unit, CEMAD Centro Malattie dell'Apparato Digerente, UOC di Medicina Interna e Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.ORCID 0000-0003-0935-8853
Federica FacciottiDipartimento di Biotecnologie e Bioscienze, University of Milan-Bicocca, Milano, Italy.
Harry SokolINSERM, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint Antoine Hospital, Gastroenterology Department, Sorbonne Universite, Paris, France.ORCID 0000-0002-2914-1822
Gianluca IaniroDipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Roma, Italy.ORCID 0000-0002-8318-0515
Luca MasucciDepartment of Laboratory Sciences and Infectious Diseases, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.
Maria AbreuDepartment of Medicine, Division of Gastroenterology, Crohn's and Colitis Center, University of Miami Miller School of Medicine, Miami, Florida, USA.
Iris DotanDivision of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel.
Samuel Paul CostelloDepartment of Gastroenterology, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia.ORCID 0000-0002-2857-1812
Ailsa HartIBD Unit, Saint Mark's Hospital, Harrow, UK.
Tariq H IqbalMicrobiome Treatment Center, University of Birmingham, Birmingham, UK.
Sudarshan ParamsothyGastroenterology and Liver Services, Concord Repatriation General Hospital, Sydney, New South Wales, Australia.
Maurizio SanguinettiDepartment of Laboratory Sciences and Infectious Diseases, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.
Silvio DaneseGastroenterology and Endoscopy, IRCCS Ospedale San Raffaele and University Vita-Salute San Raffaele, Milano, Italy.ORCID 0000-0001-7341-1351
Herbert TilgDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medizinische Universitat Innsbruck, Innsbruck, Austria.ORCID 0000-0002-4235-2579
Fabio CominelliDivision of Gastroenterology and Liver Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.ORCID 0000-0002-1571-1548
Theresa T PizarroDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Alessandro ArmuzziDeparment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy.
Giovanni CammarotaDipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Roma, Italy.ORCID 0000-0002-3626-6148
Antonio GasbarriniIBD Unit, CEMAD Centro Malattie dell'Apparato Digerente, UOC di Medicina Interna e Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.
Séverine Vermeire *Department of Chronic Diseases & Metabolism (CHROMETA), KU Leuven, Leuven, Belgium.ORCID 0000-0001-9942-3019
Franco Scaldaferri *IBD Unit, CEMAD Centro Malattie dell'Apparato Digerente, UOC di Medicina Interna e Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.ORCID 0000-0001-8334-7541
Università Cattolica del Sacro Cuore · ITAgostino Gemelli University Polyclinic · ITKU Leuven · BERabin Medical Center · ILUniversity School · USConcord Repatriation General Hospital · AUHumanitas University · ITInnsbruck Medical University · ATInserm · FRIRCCS Ospedale San Raffaele · ITQueen Elizabeth Hospital · AUSt Mark's Hospital · GBUniversity of Birmingham · GBUniversity of Miami · USUniversity of Milano-Bicocca · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral randomised clinical trials (RCTs) performing faecal microbiota transplantation (FMT) for the management of inflammatory bowel disease (IBD), particularly for ulcerative colitis, have recently been published, but with major variations in study design. These include differences in administered dose, route and frequency of delivery, type of placebo and evaluated endpoints. Although the overall outcomes appear to be promising, they are highly dependent on both donor and recipient factors.

objectiveTo develop concensus-based statements and recommendations for the evaluation, management and potential treatment of IBD using FMT in order to move towards standardised practices.

designAn international panel of experts convened several times to generate evidence-based guidelines by performing a deep evaluation of currently available and/or published data. Twenty-five experts in IBD, immunology and microbiology collaborated in different working groups to provide statements on the following key issues related to FMT in IBD: (A) pathogenesis and rationale, (B) donor selection and biobanking, (C) FMT practices and (D) consideration of future studies and perspectives. Statements were evaluated and voted on by all members using an electronic Delphi process, culminating in a plenary consensus conference and generation of proposed guidelines. RESULTS AND

conclusionsOur group has provided specific statements and recommendations, based on best available evidence, with the end goal of providing guidance and general criteria required to promote FMT as a recognised strategy for the treatment of IBD.

Indexed as

Colitis, UlcerativeGastrointestinal MicrobiomeInflammatory Bowel DiseasesFecal Microbiota TransplantationHumansRomeTreatment OutcomeINFLAMMATORY BOWEL DISEASEINTESTINAL MICROBIOLOGYULCERATIVE COLITIS

Identifiers

PMID37339849
PMCPMC10423477
OpenAlexW4381332205

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.