ArticleAmerican journal of human genetics2023
Autoimmune alleles at the major histocompatibility locus modify melanoma susceptibility.
Open access · hybridAbstract read
In one paragraph
Article in American journal of human genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- Autoimmune HLA alleles and neoantigens predict myelodysplastic syndrome outcomes after allogeneic HSCT: A CIBMTR analysis.iScience · 2026Article
- Exosomes in Autoimmunity: Mediators of Autoantigen Presentation and Targets for Therapeutic Intervention in Autoimmune Diseases.Journal of clinical immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 8 institutions in 1 country.
James V TalwarDepartment of Medicine, Division of Medical Genetics, University of California San Diego, La Jolla, CA 92093, USA; Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA 92093, USA.
David LaubDepartment of Medicine, Division of Medical Genetics, University of California San Diego, La Jolla, CA 92093, USA; Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA 92093, USA.
Meghana S PagadalaBiomedical Science Program, University of California San Diego, La Jolla, CA 92093, USA.
Andrea CastroDepartment of Medicine, Division of Medical Genetics, University of California San Diego, La Jolla, CA 92093, USA; Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA 92093, USA.
McKenna LewisDepartment of Computer Science and Engineering, University of California San Diego, La Jolla, CA 92093, USA.
Georg E LuebeckPublic Health Sciences Division, Herbold Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Bryan R GormanCenter for Data and Computational Sciences (C-DACS), VA Boston Healthcare System, Boston, MA 02130, USA; Booz Allen Hamilton, Inc., McLean, VA 22102, USA.
Cuiping PanPalo Alto Epidemiology Research and Information Center for Genomics, VA Palo Alto, CA, USA.
Frederick N DongCenter for Data and Computational Sciences (C-DACS), VA Boston Healthcare System, Boston, MA 02130, USA; Booz Allen Hamilton, Inc., McLean, VA 22102, USA.
Kyriacos MarkianosCenter for Data and Computational Sciences (C-DACS), VA Boston Healthcare System, Boston, MA 02130, USA; Division of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02115, USA.
Craig C TeerlinkDepartment of Veterans Affairs Informatics and Computing Infrastructure (VINCI), VA Salt Lake City Healthcare System, Salt Lake City, UT, USA; Department of Internal Medicine, Division of Epidemiology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Julie LynchDepartment of Veterans Affairs Informatics and Computing Infrastructure (VINCI), VA Salt Lake City Healthcare System, Salt Lake City, UT, USA; Department of Internal Medicine, Division of Epidemiology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Richard HaugerVA San Diego Healthcare System, La Jolla, CA, USA; Center for Behavioral Genetics of Aging, University of California San Diego, La Jolla, CA, USA; Center of Excellence for Stress and Mental Health (CESAMH), VA San Diego Healthcare System, San Diego, CA, USA.
Saiju PyarajanCenter for Data and Computational Sciences (C-DACS), VA Boston Healthcare System, Boston, MA 02130, USA; Department of Medicine, Brigham Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Philip S TsaoPalo Alto Epidemiology Research and Information Center for Genomics, VA Palo Alto, CA, USA; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Gerald P MorrisDepartment of Pathology, University of California San Diego, La Jolla, CA 92093, USA.
Rany M SalemDivision of Epidemiology, Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA 92093, USA.
Wesley K ThompsonCenter for Population Neuroscience and Genetics, Laureate Institute for Brain Research, Tulsa, OK 74136, USA.
Kit CurtiusBioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA 92093, USA; Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA; Division of Biomedical Informatics, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Maurizio ZanettiMoores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA; The Laboratory of Immunology, University of California San Diego, La Jolla, CA 92093, USA; Department of Medicine, Division of Hematology and Oncology, University of California San Diego, La Jolla, CA 92093, USA.
Hannah CarterDepartment of Medicine, Division of Medical Genetics, University of California San Diego, La Jolla, CA 92093, USA; Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA 92093, USA; Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: hkcarter@health.ucsd.edu.
University of California San Diego · USBooz Allen Hamilton (United States) · USUniversity of Utah · USBrigham and Women's Hospital · USBroad Institute · USFred Hutch Cancer Center · USLaureate Institute for Brain Research · USPalo Alto University · US
Funding
TR&D 3 - Network Guided Machine LearningP41GM103504 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BADER, GARY D. · 2012 to 2024
$17.3MSan Diego Biomedical Informatics Education & Research (SABER)T15LM011271 · NLM · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHAMIM NEMATI · 2012 to 2026
$9.7MTHE CANCER EPITOPE DATABASE AND ANALYSIS RESOURCEU24CA248138 · NCI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI PETERS, BJOERN, SETTE, ALESSANDRO · 2021 to 2025
$4.6MIdentifying and quantifying genetic effects on neurodevelopmental trajectories in adolescentsR01MH122688 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FAN, CHUN CHIEH · 2020 to 2024
$1.8M(PQ3) Disruption of immune surveillance by aneuploidy and aberrant MHCII expressionR01CA220009 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CARTER, HANNAH KATHRYN, ZANETTI, MAURIZIO · 2017 to 2021
$1.5MClinical Manipulation of Testosterone and Its Impact on Dementia and HealthI01CX001727 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI HAUGER, RICHARD L · 2019 to 2023
–CSRD VA I01 CX001727NCI NIH HHS R01 CA220009NCI NIH HHS U24 CA248138NIGMS NIH HHS P41 GM103504NIMH NIH HHS R01 MH122688NLM NIH HHS T15 LM011271
Abstract
Autoimmunity and cancer represent two different aspects of immune dysfunction. Autoimmunity is characterized by breakdowns in immune self-tolerance, while impaired immune surveillance can allow for tumorigenesis. The class I major histocompatibility complex (MHC-I), which displays derivatives of the cellular peptidome for immune surveillance by CD8
Indexed as
MelanomaSkin NeoplasmsAllelesCD8-Positive T-LymphocytesHistocompatibilityHistocompatibility Antigens Class IHumansHistocompatibility Antigens Class Iautoimmunitymajor histocompatibility complexmelanomapolygenic risk scores
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.