Evidence map›Paper›PMID 37339372›Full record

ArticleInhalation toxicology

Natural mineral fibers: conducting inhalation toxicology studies-part B: development of a nose-only exposure system for repeat-exposure

Anbo Wang, Amit Gupta, Michael D Grimm, David T Pressburger, Barney R Sparrow, Jamie S Richey, John R Shaw, Karen E Elsass, Georgia K Roberts, Pei-Li Yao and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inhalation toxicology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Anbo WangAmplifyBio, West Jefferson, OH, USA.ORCID 0009-0001-6185-4240
Amit GuptaBattelle Memorial Institute, Columbus, OH, USA.
Michael D GrimmAmplifyBio, West Jefferson, OH, USA.
David T PressburgerBattelle Memorial Institute, Columbus, OH, USA.
Barney R SparrowBattelle Memorial Institute, Columbus, OH, USA.
Jamie S RicheyBattelle Memorial Institute, Columbus, OH, USA.ORCID 0000-0003-1420-9203
John R ShawBattelle Memorial Institute, Columbus, OH, USA.ORCID 0009-0004-0647-2495
Karen E ElsassAmplifyBio, West Jefferson, OH, USA.
Georgia K RobertsDivision of Translational Toxicology, National Institute of Environmental Health Sciences of the U.S., Research Triangle Park, NC, USA.ORCID 0000-0003-1933-7482
Pei-Li YaoDivision of Translational Toxicology, National Institute of Environmental Health Sciences of the U.S., Research Triangle Park, NC, USA.ORCID 0000-0003-0832-3771
Matthew D StoutDivision of Translational Toxicology, National Institute of Environmental Health Sciences of the U.S., Research Triangle Park, NC, USA.
Benjamin J EllisEMSL Analytical Inc., Cinnaminson, NJ, USA.
Robyn L RayEMSL Analytical Inc., Cinnaminson, NJ, USA.ORCID 0000-0002-0130-8870
Battelle · USTriangle · US

Funding

Toxicological Assessments for the Division of the National Toxicology ProgramZICES103316 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WALKER, NIGEL J · 2020 to 2021
$18.5M
Occupational and Inhalation Exposures Research ProgramZIAES103374 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI RYAN, KRISTEN · 2022 to 2025
$11.1M
Intramural NIH HHS ZIA ES103374Intramural NIH HHS ZIC ES103316NIEHS NIH HHS HHSN273201400015C
6 · The paper itself

Abstract

backgroundExposure to asbestos is associated with malignant and nonmalignant respiratory disease. To strengthen the scientific basis for risk assessment on fibers, the National Institute of Environmental Health Sciences (NIEHS) has initiated a series of studies to address fundamental questions on the toxicology of naturally occurring asbestos and related mineral fibers after inhalation exposure. A prototype nose-only exposure system was previously developed and validated. The prototype system was expanded to a large-scale exposure system in this study for conducting subsequent

resultsThe exposure system consisting of six exposure carousels was able to independently deliver stable LA 2007 aerosol to individual carousels at target concentrations of 0 (control group), 0.1, 0.3, 1, 3, or 10 mg/m

conclusionThe exposure system developed is ready for use in conducting nose-only inhalation toxicity studies of LA 2007 in rats. The exposure system is anticipated to have applicability for the inhalation toxicity evaluation of other natural mineral fibers of concern.

Indexed as

AsbestosAsbestos, AmphiboleAerosolsAnimalsInhalation ExposureMineral FibersRatsAerosolsAsbestosAsbestos, AmphiboleMineral Fibersaerosol generationAsbestosfiberinhalation toxicologyLibby amphibole

Identifiers

PMID37339372
PMCPMC11059106
OpenAlexW4381429137

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.