Evidence map›Paper›PMID 37339263›Full record

ArticleRNA biology2023

Novel compounds that synergize with aminoglycoside G418 or eRF3 degraders for translational readthrough of nonsense mutant

Angelos Heldin, Matko Cancer, Mireia Palomar-Siles, Susanne Öhlin, Meiqiongzi Zhang, Alexander Sun-Zhang, Anna Mariani, Jianping Liu, Vladimir J N Bykov, Klas G Wiman

Open access · goldAbstract read
In one paragraph

Article in RNA biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. RiboScreenBiomedicines · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Therapeutic targeting ofUpsala journal of medical sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Angelos HeldinDepartment of Oncology-Pathology, BioClinicum, Karolinska Institutet, Stockholm, Sweden.
Matko CancerDepartment of Oncology-Pathology, BioClinicum, Karolinska Institutet, Stockholm, Sweden.
Mireia Palomar-SilesDepartment of Oncology-Pathology, BioClinicum, Karolinska Institutet, Stockholm, Sweden.
Susanne ÖhlinDepartment of Oncology-Pathology, BioClinicum, Karolinska Institutet, Stockholm, Sweden.
Meiqiongzi ZhangDepartment of Oncology-Pathology, BioClinicum, Karolinska Institutet, Stockholm, Sweden.
Alexander Sun-ZhangDepartment of Oncology-Pathology, BioClinicum, Karolinska Institutet, Stockholm, Sweden.
Anna MarianiDepartment of Oncology-Pathology, BioClinicum, Karolinska Institutet, Stockholm, Sweden.
Jianping LiuDepartment of Medicine, Karolinska Institutet, Huddinge, Sweden.
Vladimir J N BykovDepartment of Oncology-Pathology, BioClinicum, Karolinska Institutet, Stockholm, Sweden.
Klas G WimanDepartment of Oncology-Pathology, BioClinicum, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-7113-524X
Karolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The

Indexed as

AminoglycosidesNeoplasmsAnti-Bacterial AgentsCodon, NonsenseGentamicinsHumansPeptide Termination FactorsProtein Synthesis InhibitorsPTEN PhosphohydrolaseTumor Suppressor Protein p53AminoglycosidesAnti-Bacterial Agentsantibiotic G 418Codon, NonsenseGentamicinspeptide-chain-release factor 3Peptide Termination FactorsProtein Synthesis InhibitorsPTEN PhosphohydrolasePTEN protein, humanTP53 protein, humanTumor Suppressor Protein p53nonsense mutationnovel compoundsPTENsynergyTP53translational readthrough

Identifiers

PMID37339263
PMCPMC10283442
OpenAlexW4381433240

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.