Evidence map›Paper›PMID 37339205›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Natural genetic variation in the pheromone production of

Daehan Lee, Bennett W Fox, Diana Fajardo Palomino, Oishika Panda, Francisco J Tenjo, Emily J Koury, Kathryn S Evans, Lewis Stevens, Pedro R Rodrigues, Aiden R Kolodziej and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Nematode Pheromones: Structures and Functions.Molecules (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Daehan LeeDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208.ORCID 0000-0002-0546-8484
Bennett W FoxBoyce Thompson Institute, Cornell University, Ithaca, NY 14850.
Diana Fajardo PalominoBoyce Thompson Institute, Cornell University, Ithaca, NY 14850.ORCID 0009-0003-7041-1841
Oishika PandaBoyce Thompson Institute, Cornell University, Ithaca, NY 14850.
Francisco J TenjoBoyce Thompson Institute, Cornell University, Ithaca, NY 14850.
Emily J KouryDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208.ORCID 0000-0001-7869-504X
Kathryn S EvansDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208.
Lewis StevensDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208.
Pedro R RodriguesBoyce Thompson Institute, Cornell University, Ithaca, NY 14850.
Aiden R KolodziejBoyce Thompson Institute, Cornell University, Ithaca, NY 14850.
Frank C SchroederBoyce Thompson Institute, Cornell University, Ithaca, NY 14850.ORCID 0000-0002-4420-0237
Erik C AndersenDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208.ORCID 0000-0003-0229-9651

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Small molecule signaling in C. elegansR35GM131877 · NIGMS · BOYCE THOMPSON INST FOR PLANT RESEARCH · PI Frank Clemens Schroeder · 2019 to 2026
$5.0M
NIGMS NIH HHS R35 GM131877NIH HHS P40 OD010440
6 · The paper itself

Abstract

From bacterial quorum sensing to human language, communication is essential for social interactions. Nematodes produce and sense pheromones to communicate among individuals and respond to environmental changes. These signals are encoded by different types and mixtures of ascarosides, whose modular structures further enhance the diversity of this nematode pheromone language. Interspecific and intraspecific differences in this ascaroside pheromone language have been described previously, but the genetic basis and molecular mechanisms underlying the variation remain largely unknown. Here, we analyzed natural variation in the production of 44 ascarosides across 95 wild

Indexed as

Caenorhabditis elegansNematodaAnimalsGenetic VariationGenome-Wide Association StudyHumansPheromonesPheromonesascarosideC. elegansfatty acid metabolismnatural variationpheromone

Identifiers

PMID37339205
PMCPMC10293855

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.